Nicotinic acetylcholine binding sites in Alzheimer's disease

PJ Whitehouse, AM Martino, PG Antuono… - Brain research, 1986 - Elsevier
In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the
cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study,[3 …

[引用][C] Development of muscarinic agonists for the symptomatic treatment of Alzheimer's disease

JC Jaen, RD Schwarz - … Treatment of Alzheimer's Disease: Molecular and …, 1997

Studies of Central Nervous System Cholinergic Receptors in Alzheimer's Disease (AD)

M Watson, X Ming, S Vincent, SC Zhang… - Basic, Clinical, and …, 1990 - Springer
Much attention has focused on changes in muscarinic acetylcholine receptors (mAChR) in
AD. Binding, biochemical and radioautographic studies of human postmortem brain tissue …

[HTML][HTML] Cholinergic receptors in aging and Alzheimer's disease

PJ Whitehouse, KS Au - Progress in Neuro-Psychopharmacology and …, 1986 - Elsevier
Abstract Whitehouse, Peter J. and Kin Sing Au: Cholinergic receptors in aging and
Alzheimer's disease. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1986, 10 (3–5): 665 …

[PDF][PDF] Acetylcholine: I Muscarinic receptors

G Pepeu, MG Giovannini - From messengers to molecules …, 2004 - ndl.ethernet.edu.et
The study of brain muscarinic receptors began more than a century ago, long before the
existence of muscarinic receptors was postulated and then demonstrated. However, the …

Muscarinic partial agonists in the symptomatic treatment of Alzheimer's disease

R Kumar, E Cedar, MSG Clark, JM Loudon… - … : From Molecular Biology …, 1996 - Springer
In the late 1970s a profound and consistent loss of choline acetyl transferase (CT), a
presynaptic marker for acetylcholine (ACh), was observed in the brains of Alzheimer disease …

Normal sequences of muscarinic acetylcholine receptors (m1 and m2) in patients with Alzheimer's disease and vascular dementia

K Ohara, N Kondo, D Xie, K Tanabe, T Yamamoto… - Neuroscience …, 1994 - Elsevier
The genes for muscarinic acetylcholine receptors, m1 and m2, were studied in autopsied
brains from nine Alzheimer's disease, six vascular dementia and three control. The genes …

[引用][C] Neuronal nicotinic receptors: potential treatment of Alzheimer's disease with novel cholinergic channel modulators

MW Decker, JD Brioni - Pharmacological Treatment of …, 1997 - Wiley-Liss: New York

[PDF][PDF] Muscarinic cholinoceptive systems: Distribution of muscarinic receptors and behaviorally induced plasticity in the brain

EA van der Zee - 1993 - research.rug.nl
Acetylcholine (ACh) is de oudste bekende neurotransmitter in de hersenen. ACh wordt
gesynthetiseerd door zenuwcellen die tezamen het basale cholinerge voorhersensysteem …

Muscarinic receptor compensation in hippocampus of Alzheimer patients

A Nordberg, C Larsson, R Adolfsson, I Alafuzoff… - Journal of Neural …, 1983 - Springer
The activity of the acetylcholine synthesizing enzyme choline acetyltransferase
(ChAT)(presynaptic marker) and number of muscarine-like receptor binding sites have been …