Expanding the RNA virosphere by unbiased metagenomics

YZ Zhang, YM Chen, W Wang, XC Qin… - Annual Review of …, 2019 - annualreviews.org
Although viruses comprise the most abundant genetic material in the biosphere, to date only
several thousand virus species have been formally defined. Such a limited perspective on …

[HTML][HTML] Using metagenomics to characterize an expanding virosphere

YZ Zhang, M Shi, EC Holmes - Cell, 2018 - cell.com
We know less about viruses than any other lifeform. Fortunately, metagenomics has led to a
massive expansion in the known diversity of the virosphere. Here, we discuss how …

[HTML][HTML] A decade of RNA virus metagenomics is (not) enough

AL Greninger - Virus research, 2018 - Elsevier
It is hard to overemphasize the role that metagenomics has had on our recent understanding
of RNA virus diversity. Metagenomics in the 21st century has brought with it an explosion in …

Meta-transcriptomics and the evolutionary biology of RNA viruses

M Shi, YZ Zhang, EC Holmes - Virus research, 2018 - Elsevier
Metagenomics is transforming the study of virus evolution, allowing the full assemblage of
virus genomes within a host sample to be determined rapidly and cheaply. The genomic …

[HTML][HTML] Metagenomics reshapes the concepts of RNA virus evolution by revealing extensive horizontal virus transfer

VV Dolja, EV Koonin - Virus research, 2018 - Elsevier
Virus metagenomics is a young research filed but it has already transformed our
understanding of virus diversity and evolution, and illuminated at a new level the …

[HTML][HTML] Discovering the phylodynamics of RNA viruses

EC Holmes, BT Grenfell - PLoS computational biology, 2009 - journals.plos.org
The advent of extremely high throughput DNA sequencing ensures that genomic data from
microbial organisms can be acquired in unprecedented quantities and with remarkable …

RNA viromes from terrestrial sites across China expand environmental viral diversity

YM Chen, S Sadiq, JH Tian, X Chen, XD Lin… - Nature …, 2022 - nature.com
Environmental RNA viruses are ubiquitous and diverse, and probably have important
ecological and biogeochemical impacts. Understanding the global diversity of RNA viruses …

Exploring the viral world through metagenomics

K Rosario, M Breitbart - Current opinion in virology, 2011 - Elsevier
Viral metagenomics, or shotgun sequencing of purified viral particles, has revolutionized the
field of environmental virology by allowing the exploration of viral communities in a variety of …

[HTML][HTML] Metagenomics in virology

S Roux, J Matthijnssens, BE Dutilh - Encyclopedia of Virology, 2021 - ncbi.nlm.nih.gov
Metagenomics, ie, the sequencing and analysis of genomic information extracted directly
from clinical or environmental samples, has become a fundamental tool to explore the viral …

Redefining the invertebrate RNA virosphere

M Shi, XD Lin, JH Tian, LJ Chen, X Chen, CX Li… - Nature, 2016 - nature.com
Current knowledge of RNA virus biodiversity is both biased and fragmentary, reflecting a
focus on culturable or disease-causing agents. Here we profile the transcriptomes of over …