The role of eosinophils in the development and progression of chronic allograft rejection is
recognized in multiple organ transplantation settings. The CCR3 signaling pathway is one of …

Despite the accepted notion that granulocytes play a universally destructive role in organ
and tissue grafts, it has been recently described that eosinophils can facilitate …

To clarify the role and regulation of eosinophils, we subjected several key eosinophil-related
genetically engineered mice to a chronic model of allergic airway inflammation aiming to …

Eosinophilic chronic rhinosinusitis (ECRS) is a refractory airway disease accompanied by
eosinophilic inflammation, the mechanisms of which are unknown. We recently found that …

How eosinophils are preferentially recruited to inflammatory sites remains elusive, but
increasing evidence suggests that chemokines that bind to the CCR3 participate in this …

Allergic rhinitis (AR) is characterized by various bothersome clinical symptoms of the nasal
mucosa that impaired the quality of daily life. Different chemokine receptors play a crucial …

Eotaxin is an eosinophil-specific C–C chemokine that is implicated in the pathogenesis of
eosinophilic inflammatory diseases, such as asthma and atopic dermatitis, by acting …

Background: The chemokine eotaxin is produced at sites of allergic inflammation, binds
selectively to the chemokine receptor CCR3 and attracts eosinophil and basophil …

The eotaxin chemokines have been implicated in allergen-induced eosinophil responses in
the lung. However, the individual and combined contribution of each of the individual …

Eosinophils are major effector cells implicated in a number of chronic inflammatory diseases
in humans, particularly bronchial asthma and allergic rhinitis. The β-chemokine receptor CC …