[HTML][HTML] PDXGEM: patient-derived tumor xenograft-based gene expression model for predicting clinical response to anticancer therapy in cancer patients
Background Cancer is a highly heterogeneous disease with varying responses to anti-
cancer drugs. Although several attempts have been made to predict the anti-cancer …
cancer drugs. Although several attempts have been made to predict the anti-cancer …
[HTML][HTML] Integrated analysis of transcriptome in cancer patient-derived xenografts
Patient-derived xenograft (PDX) tumor model is a powerful technology in evaluating anti-
cancer drugs and facilitating personalized medicines. Multiple research centers and …
cancer drugs and facilitating personalized medicines. Multiple research centers and …
Personalized cancer therapy using a patient-derived tumor tissue xenograft model: a translational field worthy of exploring further?
K Jin, K He, G Li, L Teng - Personalized Medicine, 2010 - Taylor & Francis
It has long been observed that interpatient variability in response to anticancer drugs is
associated with different outcomes. Oncologists continually hold the desire of matching the …
associated with different outcomes. Oncologists continually hold the desire of matching the …
[HTML][HTML] Concise polygenic models for cancer-specific identification of drug-sensitive tumors from their multi-omics profiles
In silico models to predict which tumors will respond to a given drug are necessary for
Precision Oncology. However, predictive models are only available for a handful of cases …
Precision Oncology. However, predictive models are only available for a handful of cases …
Know thy PDX model
TF Meehan - Cancer Research, 2019 - AACR
Patient-derived tumor xenograft (PDX) models are frequently used to study cancer
mechanisms and potential therapeutics, however, differences in tumor evolution between …
mechanisms and potential therapeutics, however, differences in tumor evolution between …
[HTML][HTML] Primary tumor site specificity is preserved in patient-derived tumor xenograft models
Patient-derived tumor xenograft (PDX) mouse models are widely used for drug screening.
The underlying assumption is that PDX tissue is very similar with the original patient tissue …
The underlying assumption is that PDX tissue is very similar with the original patient tissue …
Integrative pharmacogenomics analysis of patient-derived xenografts
Identifying robust biomarkers of drug response constitutes a key challenge in precision
medicine. Patient-derived tumor xenografts (PDX) have emerged as reliable preclinical …
medicine. Patient-derived tumor xenografts (PDX) have emerged as reliable preclinical …
[HTML][HTML] Patient-derived xenograft models in cancer research
WM van Weerden - Cancers, 2021 - mdpi.com
This series of 12 articles, consisting of 9 original articles and 3 reviews, is presented by
international leaders in translational cancer research. This series highlights the various …
international leaders in translational cancer research. This series highlights the various …
PRECISE: a domain adaptation approach to transfer predictors of drug response from pre-clinical models to tumors
Motivation Cell lines and patient-derived xenografts (PDXs) have been used extensively to
understand the molecular underpinnings of cancer. While core biological processes are …
understand the molecular underpinnings of cancer. While core biological processes are …
Evaluating cancer cell line and patient‐derived xenograft recapitulation of tumor and non‐diseased tissue gene expression profiles in silico
Background Preclinical models like cancer cell lines and patient‐derived xenografts (PDXs)
are vital for studying disease mechanisms and evaluating treatment options. It is essential …
are vital for studying disease mechanisms and evaluating treatment options. It is essential …