Evidence obtained over the past two decades shows that reactive oxygen species (ROS) are
involved in brain lesions, including those due to cerebral ischemia-reperfusion. The …

Stroke is a main cause of mortality and morbidity worldwide. Despite the increasing
development of innovative treatments for stroke, most are unsuccessful in clinical trials. In …

Stroke is a devastating disease with high mortality and disability rates. Previous research
has established that mitochondria, as major regulators, are both influenced by stroke, and …

Stroke most commonly results from occlusion of a major artery in the brain and typically
leads to the death of all cells within the affected tissue. Mitochondria are centrally involved in …

Mitochondrial dysfunctions are among the main hallmarks of several brain diseases,
including ischemic stroke. An insufficient supply of oxygen and glucose in brain cells …

Apoptotic cell death pathways have been implicated in acute brain injuries, including
cerebral ischemia, brain trauma, and spinal cord injury, and in chronic neurodegenerative …

Stroke is one of the leading causes of death and long-term disability worldwide. More than
80% of strokes are ischemic, caused by an occlusion of cerebral arteries. Without question …

Cerebral ischemia results in a poor oxygen supply and cerebral infarction. Reperfusion to
the ischemic area is the best therapeutic approach. Although reperfusion after ischemia has …

Stroke is a debilitating disease that remains the second leading cause of death and
disability worldwide. Despite accumulating knowledge of the disease pathology, treatments …

Stroke and circulatory arrest cause interferences in blood flow to the brain that result in
considerable tissue damage. The primary method to reduce or prevent neurologic damage …