In cerebral tissues, due to continuous and high metabolic demand, energy is produced
exclusively by mitochondrial oxidative phosphorylation (OXPHOS). Obstruction of blood flow …

We review research investigating mitochondrial damage during heart and brain ischaemia,
focusing on the mechanisms and consequences of ischaemia‐induced and/or reperfusion …

Research on ischemic brain injury has established a central role of mitochondria in neuron
death (1–3). Astrocytes are also damaged by ischemia (4), although the participation of …

Ischemic stroke is a severe cerebrovascular disease with high mortality and morbidity. In
recent years, reperfusion treatments based on thrombolytic and thrombectomy are major …

Central nervous system (CNS) diseases, both traumatic and neurodegenerative, are
characterized by impaired mitochondrial bioenergetics and often disturbed mitochondrial …

The advent of epigenetics brought in a tectonic shift in the understanding of molecular basis
of complex diseases like ischemic stroke (IS). Substantial scientific inquiry into the …

Background and Purpose—Mitochondrial swelling is one of the most striking and initial
ultrastructural changes after acute brain ischemia. The purpose of the present study was to …

Mitochondria are key cytoplasmic organelles, responsible for generating cellular energy,
regulating intracellular calcium levels, altering the reduction-oxidation potential of cells, and …

The brain is highly dependent on mitochondrial energy metabolism. As a result,
mitochondrial dysfunction is a central aspect of many adult-onset neurological diseases …

Background and Purpose: There is an urgent need to develop adjunct therapies that can be
added onto reperfusion for acute ischemic stroke. Recently, mitochondrial transplantation …