Age, inflammation, and disease location are critical determinants of intestinal expression of SARS-CoV-2 receptor ACE2 and TMPRSS2 in inflammatory bowel …

JK Nowak, JC Lindstrøm, R Kalla, P Ricanek… - …, 2020 - gastrojournal.org
Methods We compared RNA expression of ACE2 and TMPRSS2 in blood (paired-end
sequencing), ileal, and colonic mucosal biopsies (microarray) from 138 patients with …

Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2–related disease

M Suárez-Fariñas, M Tokuyama, G Wei, R Huang… - Gastroenterology, 2021 - Elsevier
Background and Aims The presence of gastrointestinal symptoms and high levels of viral
RNA in the stool suggest active severe acute respiratory syndrome coronavirus 2 (SARS …

Expression of SARS-CoV-2 entry molecules ACE2 and TMPRSS2 in the gut of patients with IBD

JF Burgueno, A Reich, H Hazime… - Inflammatory bowel …, 2020 - academic.oup.com
Background Patients with inflammatory bowel disease (IBD) have intestinal inflammation
and are treated with immune-modulating medications. In the face of the coronavirus disease …

Intestinal receptor of SARS-CoV-2 in inflamed IBD tissue seems downregulated by HNF4A in ileum and upregulated by interferon regulating factors in colon

B Verstockt, S Verstockt… - Journal of Crohn's …, 2021 - academic.oup.com
Background Patients with inflammatory bowel disease [IBD] are considered
immunosuppressed, but do not seem more vulnerable for COVID-19. Nevertheless …

Altered intestinal ACE2 levels are associated with inflammation, severe disease, and response to anti-cytokine therapy in inflammatory bowel disease

AA Potdar, S Dube, T Naito, K Li, G Botwin… - Gastroenterology, 2021 - Elsevier
Background And Aims The host receptor for severe acute respiratory syndrome coronavirus
2, angiotensin-converting enzyme 2 (ACE2), is highly expressed in small bowel (SB). Our …

[HTML][HTML] SARS-CoV-2 receptor ACE2 gene expression in small intestine correlates with age

RN Vuille-dit-Bille, KW Liechty, F Verrey… - Amino acids, 2020 - Springer
Gastrointestinal symptoms are common in COVID-19 patients, especially in younger
patients. Our hypothesis was that intestinal SARS-CoV-2 receptor ACE2 expression …

Diarrhoea may be underestimated: a missing link in 2019 novel coronavirus

W Liang, Z Feng, S Rao, C Xiao, X Xue, Z Lin, Q Zhang… - Gut, 2020 - gut.bmj.com
A series of pneumonia cases caused by 2019 novel coronavirus (2019-nCoV, also named
COVID-19) are being reported globally. Based on recent publications, 1–3 the most common …

[HTML][HTML] High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients

C Liu, K Wang, M Zhang, X Hu, T Hu, Y Liu… - NPJ precision …, 2021 - nature.com
Little is known of the patterns of expression of ACE2 and TMPRSS2 or the clinical
characteristics of COVID-19 in patients with COVID-19 and colorectal cancer. We found in …

[HTML][HTML] 2019 Novel coronavirus infection and gastrointestinal tract

QY Gao, YX Chen, JY Fang - Journal of digestive diseases, 2020 - ncbi.nlm.nih.gov
Since December 2019, several cases of pneumonia of unknown etiology have been
reported in Wuhan, Hubei Province, China. On 7 January 2020, a novel coronavirus was …

The thrilling journey of SARS-CoV-2 into the intestine: from pathogenesis to future clinical implications

F Scaldaferri, G Ianiro, G Privitera… - Inflammatory Bowel …, 2020 - academic.oup.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has a direct
impact on the gastrointestinal system, as up to 50% of fecal samples from coronavirus …