Blood reperfusion of affected limbs is the most effective therapy for peripheral vascular
thrombotic disease, restoring nutrition and blood flow to threatened tissues. Because it is …

Accelerating thrombolysis using plasminogen activators (PAs) encapsulated liposomes or
PEG microparticles by pressure-driven permeation have been demonstrated in vitro and in …

Ionic cross-linking of water-soluble chitosan with sodium tripolyphosphate in the presence of
recombinant tissue plasminogen activator (rtPA) and magnetite (Fe3O4) nanoparticles could …

The objective of this work was to prepare the streptokinase (SK) entrapped in chitosan
nanoparticles (CS NPs) using bulk mixing (BM) and microfluidic (MF) techniques. The …

Chitosan nanoparticles (NPs) decorated with adenosine diphosphate (ADP)(ANPs) or
fibrinogen (FNPs) were used to fabricate hemostatic NPs that can shorten blood clotting time …

Accelerated thrombolysis by pressure‐driven permeation has been demonstrated in in vitro
and in vivo animal models by using plasminogen activators (PAs) encapsulated liposomes …

The most concerning adverse effects of thrombolytic agents are major bleeding and
intracranial hemorrhage due to their short half-life, low fibrin specificity, and high dosage. To …

Lumbrokinase (LK) has strong fibrinolytic and thrombolytic activities, but it has a short half-
life, can be easily inactivated, and may cause hemorrhage as a side effect. This study …

The aim of present study was to investigate the potential of mucoadhesive polymer chitosan
(CS) and N-trimethyl chitosan (TMC) based nanoparticulate systems for oral bioavailability …

Injection of recombinant tissue plasminogen activator (rt-PA) is the standard drug treatment
for thrombolysis. However, rt-PA shows risk of hemorrhages and limited efficiency even at …