Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-
phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol …

Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step during de
novo synthesis of triacylglycerol. It has been well recognized that mammals possess multiple …

Abstract Glycerol-3-phosphate acyltransferase (GPAT) is the rate-limiting enzyme in the de
novo pathway of glycerolipid synthesis. It catalyzes the conversion of glycerol-3-phosphate …

AGPAT6 is a member of the 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) family
that appears to be important in triglyceride biosynthesis in several tissues, but the precise …

Glycerol-3-phosphate acyltransferases (GPATs; EC2. 3.1. 15) catalyze the first step in the de
novo synthesis of neutral lipids (triglycerides) and glycerophospholipids. The existence of …

Elucidation of the metabolic pathways of triacylglycerol (TAG) synthesis is critical to the
understanding of chronic metabolic disorders such as obesity, cardiovascular disease, and …

Acyl-CoA: glycerol-sn-3-phosphate acyltransferase (GPAT) is an enzyme responsible for the
rate-limiting step in the synthesis of glycerophospholipids and triacylglycerol (TAG). The …

Synthesis of phospholipids can occur de novo or via remodeling of the existing
phospholipids. Synthesis of triglycerides, a form of energy storage in cells, is an end product …

Loss-of-function mutations in 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) 2 in
humans and mice result in loss of both the white and brown adipose tissues from birth …

Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step during de
novo synthesis of glycerolipids. Mammals have at least four GPAT isoforms. Here we report …