Mammalian oocytes represent impaired quality after undergoing a process of postovulatory
aging, which can be alleviated through various effective ways such as reagent treatment …

After ovulation, mammalian oocytes will undergo a time-dependent process of aging if they
are not fertilized. This postovulatory aging (POA) seriously affects the oocyte quality and …

In brief Post-ovulatory ageing of oocytes leads to poor oocyte and embryo quality as well as
abnormalities in offspring. This review provides an update on the contributions of oxidative …

Reactive oxygen species (ROS) production is a normal process of cell metabolism. In vitro
environments usually increase cell production of ROS, which has been implicated as a main …

Aging oocytes undergo various molecular, cellular, and biochemical changes. Aging of
oocytes results in reduced embryo developmental capacity and blastocyst quality, which is …

Oxidative stress is known as a major contributing factor involved in oocyte aging, which
negatively affects oocyte quality and development after fertilization. Melatonin is an effective …

Sorbitol is a product of glucose metabolism through the polyol pathway. Many studies have
demonstrated that excessive sorbitol can disrupt the intracellular redox balance. However …

Mechanisms for post-maturation oocyte aging (PMOA) are not fully understood, and whether
autophagy plays any role in PMOA is unknown. To explore the role of autophagy in PMOA …

Oocytes from aging ovaries contain mitochondria with morphological and genetic flaws. How
these flaws relate to phenotypes of oocyte developmental compromise associated with …

Background Oocytes may undergo two types of aging. The first is induced by exposure to an
aged ovarian microenvironment before being ovulated, known as 'reproductive or maternal …