Female aging is one of the most important factors that impacts human reproduction. With
aging, there is a natural decline in female fertility. The decrease in fertility is slow and steady …

Francesca E. Duncan and Jennifer L. Gerton www. aging-us. com 162 AGING www. aging-
us. com AGIING 2018, Vol. 10, No. 2 related to mitochondria, chromosomes, kinetochores …

Nitric oxide (NO) is a ubiquitous signaling molecule that plays a crucial role in oocyte
maturation and embryo development. However, its role in oocyte aging is unclear. To …

If fertilization does not occur for a prolonged period in vivo or in vitro, the postovulatory
oocytes will deteriorate, which called the postovulatory aging. This process disrupts the …

Ageing severely affects the chromosome segregation process in human oocytes resulting in
aneuploidy, infertility and developmental disorders. A considerable amount of segregation …

This study aims (i) to ascertain whether oxidative-stress-induced disturbances in
chromosomal distribution in the metaphase-II spindle of mouse oocytes can be counteracted …

In the efforts aimed at improving the quality of in-vitro-matured human oocytes, the dynamic
balance and roles of pro-/antioxidants merit further consideration. In-vitromaturation (IVM) is …

STUDY QUESTION Are human ovarian aging and the age-related female fertility decline
caused by oxidative stress and mitochondrial dysfunction in oocytes? SUMMARY ANSWER …

Hyperthermia during estrus has direct consequences on the maturing oocyte that carries
over to the resultant embryo to compromise its ability to continue in development. Because …

Oxidative stress has been implicated in various aspects of aging, but the role of oxidative
stress in ovarian aging remains unclear. Our previous studies have shown that the initiation …