Arginine is a precursor for the synthesis of urea, polyamines, creatine phosphate, nitric oxide
and proteins. It is synthesized from ornithine by argininosuccinate synthetase and …

Rat kidneys extract citrulline derived from the intestinal metabolism of glutamine and convert
it stoichiometrically into arginine. This pathway constitutes the major endogenous source of …

Arginase 1 and arginase 2 catalyze the hydrolysis of arginine to ornithine and urea. The
localization of these enzymes was studied in various tissues in Sprague–Dawley rats by …

Liver-type arginase (arginase I) is expressed almost exclusively in the liver and catalyzes
the last step of urea synthesis, whereas the nonhepatic type (arginase II) is expressed in …

Arginase, which catalyzes the conversion of arginine to urea and ornithine, and consists of a
liver-type (arginase I) and a non-hepatic type (arginase II). Arginine is also used for the …

Arginase I (AI), the fifth and final enzyme of the urea cycle, detoxifies ammonia as part of the
urea cycle. In previous studies from others, AI was not found in extrahepatic tissues except in …

There are two forms of arginase in humans, both catalyzing the hydrolysis of arginine to
ornithine and urea. Recent studies in animal models and in Type I arginase-deficient …

Human type II arginase, which is extrahepatic and mitochondrial in location, catalyzes the
hydrolysis of arginine to form ornithine and urea. While type I arginases function in the net …

Cirrhosis leads to an inability of the liver to perform its biochemical functions. It can also lead
to hepatocellular carcinoma in which, as we showed lately, arginase isoenzyme pattern …

Arginase A1 and arginase A4 were isolated from rat kidney. Arginase A4, which is the main
form of arginase in rat kidney, was obtained at a highly purified preparation; its specific …