Although heparan sulfate has been known since its discovery 50 years ago by Jorpes and
Gardell (1948), only recently has its importance to the cellular economy become apparent …

Cell surface proteoglycans are strategically positioned to regulate interactions between cells
and their surrounding environment. Such interactions play key roles in several biological …

Heparan sulfate proteoglycans are complex molecules composed of a core protein with
covalently attached glycosaminoglycan chains. While the protein part determines …

Heparan sulfate is a regulatory polysaccharide. It modulates specific growth factor‐receptor
interactions, accelerates the formation of specific proteinase‐proteinase inhibitor complexes …

Some of the proteins that are expressed at the cell surface carry one or more
glycosaminoglycan chains. A growing body of evidence suggests that these molecules are …

The molecular mechanisms that determine the interactions between cells and their
microenvironment are of central importance to the normal development and function of …

Heparan sulfate of the cell surface of cultured Chinese hamster cells (line CHO) was
promptly released when the cells were incubated with balanced salt solutions containing …

A. Introduction Heparan sulfate proteoglycans(HSPGs) are widely distributed among animal
cells, as a basic component of cell surface molecules and as a major constituent of …

▪ Abstract The heparan sulfate on the surface of all adherent cells modulates the actions of a
large number of extracellular ligands. Members of both cell surface heparan sulfate …

A PRIMER ON HEPARAN SULFATE.......................................................... Structure and
Distribution...................................................................... Protein-binding Properties …