Valsartan, a new angiotensin II antagonist for the treatment of essential hypertension: efficacy, tolerability and safety compared to an angiotensin-converting enzyme …

HR Black, A Graff, D Shute, R Stoltz, D Ruff… - Journal of Human …, 1997 - nature.com
Objective: To compare the efficacy, safety and tolerability of valsartan to an angiotensin-
converting enzyme (ACE) inhibitor, lisinopril, and placebo in patients with mild-to-moderate …

Valsartan, a new angiotensin II antagonist for the treatment of essential hypertension: efficacy and safety compared with placebo and enalapril

NJ Holwerda, R Fogari, P Angeli… - Journal of …, 1996 - journals.lww.com
Objective: To compare the antihypertensive efficacy and systemic tolerability of valsartan, a
new angiotensin II receptor antagonist, with placebo and with an angiotensin converting …

Dose-response efficacy of valsartan, a new angiotensin II receptor blocker

JL Pool, R Glazer, YT Chiang, M Gatlin - Journal of human hypertension, 1999 - nature.com
Objective: To study the efficacy and tolerability of a range of valsartan doses in patients with
mild-to-moderate hypertension. Design: 122 adult out-patients were randomised in equal …

Valsartan, a new angiotensin II antagonist for the treatment of essential hypertension: efficacy and safety compared to hydrochlorothiazide

G Hegner, G Faust, F Freytag, S Meilenbrock… - European journal of …, 1997 - Springer
Objective: To compare the antihypertensive efficacy of a new angiotensin II antagonist,
valsartan, with a reference therapy, hydrochlorothiazide (HCTZ). Methods: In this double …

Valsartan and atenolol in patients with severe essential hypertension

R Cifkova, J Peleška, J Hradec, H Rosolova… - Journal of human …, 1998 - nature.com
The aim of this study was to evaluate the efficacy and tolerability of valsartan, a new
angiotensin II receptor antagonist, versus atenolol in the treatment of severe primary …

Valsartan: a review of its pharmacology and therapeutic use in essential hypertension

A Markham, KL Goa - Drugs, 1997 - Springer
Synopsis Valsartan competitively and selectively inhibits the actions of angiotensin II at the
AT 1 receptor subtype which is responsible for most of the known effects of angiotensin II. In …

Comparison of valsartan 160 mg with lisinopril 20 mg, given as monotherapy or in combination with a diuretic, for the treatment of hypertension: the Blood Pressure …

E Malacco, M Santonastaso, NA Varì, A Gargiulo… - Clinical …, 2004 - Elsevier
Background: The goal of antihypertensive therapy is to provide good blood pressure (BP)
control without eliciting adverse effects. Objective: This study compared the risk-benefit …

The efficacy and safety of valsartan compared with placebo in the treatment of patients with essential hypertension

S Oparil, S Dyke, F Harris, J Kief, D James, A Hester… - Clinical …, 1996 - Elsevier
A multicenter, randomized, placebo-controlled, double-masked, parallel-group study was
performed to compare the efficacy and safety of valsartan 20, 80, 160, and 320 mg with …

Valsartan, a new angiotensin II antagonist: antihypertensive effects over 24 hours

J Neutel, M Weber, J Pool, D Smith, S Fitzsimmons… - Clinical …, 1997 - Elsevier
This study was done to assess the antihypertensive efficacy of once-daily valsartan 20 mg,
80 mg, 160 mg, and 320 mg over 24 hours using ambulatory blood pressure monitoring …

Valsartan, a new angiotensin II antagonist for the treatment of essential hypertension: a comparative study of the efficacy and safety against amlodipine

L Corea, O Cardoni, R Fogari… - Clinical …, 1996 - Wiley Online Library
Objective To compare the antihypertensive efficacy of a new angiotensin II antagonist,
valsartan, with a reference therapy, amlodipine. Methods One hundred sixty‐eight adult …