Chitin, a polymer of N-acetylglucosamine, is an essential component of the fungal cell wall.
Chitosan, a deacetylated form of chitin, is also important in maintaining cell wall integrity and …

Cryptococcus neoformans, an encapsulated yeast, is a common cause of life-threatening
meningoencephalitis in immunosuppressed patients. We previously observed that …

Cryptococcus neoformans is a fungal pathogen causing life-threatening
meningoencephalitis in susceptible individuals. Fungal vaccine development has been …

The high global burden of cryptococcosis has made development of a protective vaccine a
public health priority. We previously demonstrated that a vaccine composed of recombinant …

In the Damage-response framework of microbial pathogenesis, infectious diseases are one
outcome of a host-microorganism interaction in a susceptible host. In cryptococcal disease …

Genetically regulated mechanisms of host defense against Cryptococcus neoformans
infection are not well understood. In this study, pulmonary infection with the moderately …

Cryptococcus neoformans is an encapsulated fungus that is a frequent cause of
lifethreatening infections in patients with AIDS. C. neoformans has many similarities with …

Cryptococcosis is a relatively common fungal disease caused by Cryptococcus neoformans
that has high morbidity and mortality. Numerous studies have established the feasibility of …

Cryptococcus neoformans, the etiological agent of cryptococcosis, is an occasional
opportunistic fungal pathogen of immune competent individuals. However, it is a relatively …

Vaccination with glucan particles (GP) containing the Cryptococcus neoformans chitin
deacetylases Cda1 and Cda2 protect mice against experimental cryptococcosis. Here …