SLC7A11 is a cell transmembrane protein composing the light chain of system xc−,
transporting extracellular cystine into cells for cysteine production and GSH biosynthesis …

The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to
import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in …

Cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11; also known as
xCT) plays a key role in antioxidant defense by mediating cystine uptake, promoting …

Amino acid transporters mediate substrates across cellular membranes and their fine-tuned
regulations are critical to cellular metabolism, growth, and death. As the functional …

SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange
for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione …

The cystine transporter solute carrier family 7 member 11 (SLC7A11)(also known as xCT)
promotes glutathione synthesis and counters oxidative stress–induced cell death, including …

Background Solute carrier family 7 member 11 (SLC7A11) is overexpressed in multiple
human tumours and functions as a transporter importing cystine for glutathione biosynthesis …

While many anti-cancer modalities have shown potent efficacy in clinical practices, cancer
prevention, timely detection, and effective treatment are still challenging. As a newly …

Osteosarcoma (OS) is a common type of bone tumor for which there has been limited
therapeutic progress over the past three decades. The prevalence of transcriptional …

Breast cancer cells evade cell death by overexpressing SLC7A11, which functions by
transporting cystine into cells in exchange for intracellular glutamate facilitating glutathione …