Microfluidic synthesis of multifunctional liposomes for tumour targeting

R Ran, APJ Middelberg, CX Zhao - Colloids and Surfaces B: Biointerfaces, 2016 - Elsevier
Nanotechnology has started a new era in engineering multifunctional nanoparticles for
diagnosis and therapeutics by incorporating therapeutic drugs, targeting ligands, stimuli …

Microfluidic synthesis of PEG-and folate-conjugated liposomes for one-step formation of targeted stealth nanocarriers

RR Hood, C Shao, DM Omiatek, WN Vreeland… - Pharmaceutical …, 2013 - Springer
Purpose A microfluidic hydrodynamic flow focusing technique enabling the formation of
small and nearly monodisperse liposomes is investigated for continuous-flow synthesis of …

Microfluidic preparation of drug-loaded PEGylated liposomes, and the impact of liposome size on tumour retention and penetration

YD Dong, E Tchung, C Nowell, S Kaga… - Journal of liposome …, 2019 - Taylor & Francis
Understanding the effect of liposome size on tendency for accumulation in tumour tissue
requires preparation of defined populations of different sized particles. However, controlling …

Multifunctional liposomes

B Aryasomayajula, G Salzano, VP Torchilin - … : Methods and Protocols, 2017 - Springer
Liposomes have come a long way since their conception in the 1960s, when they were
envisioned primarily for drug delivery. Besides serving the important function of the delivery …

Liposomes for tumor targeted therapy: a review

S Wang, Y Chen, J Guo, Q Huang - International journal of molecular …, 2023 - mdpi.com
Liposomes, the most widely studied nano-drug carriers in drug delivery, are sphere-shaped
vesicles consisting of one or more phospholipid bilayers. Compared with traditional drug …

Investigating the application of liposomes as drug delivery systems for the diagnosis and treatment of cancer

LW Allahou, SY Madani… - International journal of …, 2021 - Wiley Online Library
Chemotherapy is the routine treatment for cancer despite the poor efficacy and associated
off‐target toxicity. Furthermore, therapeutic doses of chemotherapeutic agents are limited …

Microfluidic self-assembly of a combinatorial library of single-and dual-ligand liposomes for in vitro and in vivo tumor targeting

R Ran, H Wang, Y Liu, Y Hui, Q Sun, A Seth… - European Journal of …, 2018 - Elsevier
Precise engineering of nanoparticles with systematically varied properties (size, charge
surface properties, targeting ligands, etc.) remains a challenge, limiting the effective …

Liposomes: from a clinically established drug delivery system to a nanoparticle platform for theranostic nanomedicine

WT Al-Jamal, K Kostarelos - Accounts of chemical research, 2011 - ACS Publications
For decades, clinicians have used liposomes, self-assembled lipid vesicles, as nanoscale
systems to deliver encapsulated anthracycline molecules for cancer treatment. The more …

Liposomes: versatile and biocompatible nanovesicles for efficient biomolecules delivery

S Mallick, JS Choi - Journal of nanoscience and …, 2014 - ingentaconnect.com
Since the revolutionary discovery that phospholipids can form closed bilayered structures in
aqueous systems, liposomes have become a very interesting topic of research. Because of …

Application potential of engineered liposomes in tumor targeting

A Jain, SK Jain - … systems for combined delivery, biosensing and …, 2017 - Elsevier
Most anticancer agents are poorly water soluble and highly potent by nature, leading to
nonselective devastation of tumor, as well as normal healthy cells; this poses an obstinate …