Glucose is a vital source of energy for all mammals. The balance between glucose uptake,
metabolism and storage determines the energy status of an individual, and perturbations in …

Adipose tissue is a critical regulator of systemic metabolism and normal bodily homeostasis.
Recently, the immune system has been implicated in the regulation of adipose tissue …

Obesity is an increasingly prevalent disease worldwide. While genetic and environmental
factors are known to regulate the development of obesity and associated metabolic …

Adipose tissue (AT) plays a pivotal role in whole-body lipid and glucose homeostasis. AT
exerts metabolic control through various immunological mechanisms that instigated a new …

Inflammation is an important contributor to the pathogenesis of obesity-related type 2
diabetes (T2D). Adipose tissue-resident immune cells have been observed, and the …

Obesity-associated inflammation stems from a combination of cell-intrinsic changes of
individual immune cell subsets and the dynamic crosstalk amongst a broad array of immune …

Recent findings, notably on adipokines and adipose tissue inflammation, have revised the
concept of adipose tissues being a mere storage depot for body energy. Instead, adipose …

The signals and structure of the tissues in which leukocytes reside critically mould leukocyte
function and development and have challenged our fundamental understanding of how to …

The immune system plays a critical role in white adipose tissue (WAT) energy homeostasis
and, by extension, whole-body metabolism. Substantial evidence from mouse and human …

Over the past decade, chronic inflammation in visceral adipose tissue (VAT) has gained
acceptance as a lead promoter of insulin resistance in obesity. A great deal of evidence has …