PhieABEs: a PAM‐less/free high‐efficiency adenine base editor toolbox with wide target scope in plants

J Tan, D Zeng, Y Zhao, Y Wang, T Liu… - Plant Biotechnology …, 2022 - Wiley Online Library
Adenine base editors (ABEs), which are generally engineered adenosine deaminases and
Cas variants, introduce site‐specific A‐to‐G mutations for agronomic trait improvement …

Simplified adenine base editors improve adenine base editing efficiency in rice

K Hua, X Tao, W Liang, Z Zhang… - Plant Biotechnology …, 2020 - Wiley Online Library
Adenine base editors (ABE s) have been exploited to introduce targeted adenine (A) to
guanine (G) base conversions in various plant genomes, including rice, wheat and …

[HTML][HTML] Optimizing base editors for improved efficiency and expanded editing scope in rice

M Wang, Z Wang, Y Mao, Y Lu, R Yang… - Plant Biotechnology …, 2019 - ncbi.nlm.nih.gov
Dear Editor, Base editors, presently including cytidine base editors (CBEs) and adenine
base editors (ABEs), enable precise base alterations in the genome without inducing DNA …

[PDF][PDF] High-efficiency and multiplex adenine base editing in plants using new TadA variants

D Yan, B Ren, L Liu, F Yan, S Li, G Wang, W Sun… - Molecular plant, 2021 - cell.com
Recently reported adenine base editors (ABEs) exhibit powerful potential for targeted gene
correction as well as developing gain-of-function mutants and novel germplasms for both …

Genome editing tools in plants

TK Mohanta, T Bashir, A Hashem, EF Abd_Allah… - Genes, 2017 - mdpi.com
Genome editing tools have the potential to change the genomic architecture of a genome at
precise locations, with desired accuracy. These tools have been efficiently used for trait …

[HTML][HTML] Efficient A· T to G· C base conversions in dicots using adenine base editors expressed under the tomato EF1α promoter

Q Niu, S Wu, H Xie, Q Wu, P Liu, Y Xu… - Plant Biotechnology …, 2023 - ncbi.nlm.nih.gov
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas systems have
revolutionized plant breeding. Different Cas enzymes have been widely used to introduce …

[HTML][HTML] CRISPR/Cas9-mediated adenine base editing in rice genome

LI Hao, QIN Ruiying, LIU Xiaoshuang, L Shengxiang… - Rice Science, 2019 - Elsevier
Precise base editing is highly desired in plant functional genomic research and crop
molecular breeding. In this study, we constructed a rice-codon optimized adenine base …

Genome-and transcriptome-wide off-target analyses of a high-efficiency adenine base editor in tomato

S Sretenovic, Y Green, Y Wu, Y Cheng… - Plant …, 2023 - academic.oup.com
Adenine base editors (ABEs) are valuable, precise genome editing tools in plants. In recent
years, the highly promising ADENINE BASE EDITOR8e (ABE8e) was reported for efficient A …

[HTML][HTML] Increasing cytosine base editing scope and efficiency with engineered Cas9-PmCDA1 fusions and the modified sgRNA in rice

Y Wu, W Xu, F Wang, S Zhao, F Feng, J Song… - Frontiers in …, 2019 - frontiersin.org
Base editors that do not require double-stranded DNA cleavage or homology-directed repair
enable higher efficiency and cleaner substitution of targeted single nucleotides in genomic …

A large-scale genome and transcriptome sequencing analysis reveals the mutation landscapes induced by high-activity adenine base editors in plants

S Li, L Liu, W Sun, X Zhou, H Zhou - Genome Biology, 2022 - Springer
Background The high-activity adenine base editors (ABEs), engineered with the recently-
developed tRNA adenosine deaminases (TadA8e and TadA9), show robust base editing …