Single-cell RNA sequencing reveals a novel cell type and immunotherapeutic targets in papillary thyroid cancer

Z Wang, Y Rixiati, W Jiang, C Ye, C Huang, C Tang… - medRxiv, 2021 - medrxiv.org
Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Although PTC
usually has a favorable prognosis, some aggressive PTC subtypes and lymph node (LN) …

Single-cell RNA sequencing revealed a 3-gene panel predicted the diagnosis and prognosis of thyroid papillary carcinoma and associated with tumor immune …

Z Chen, Y Wang, D Li, Y Le, Y Han, L Jia, C Yan… - Frontiers in …, 2022 - frontiersin.org
Objective The objective of this research was to screen prognostic related genes of thyroid
papillary carcinoma (PTC) by single-cell RNA sequencing (scRNA-seq), to construct the …

Single‐cell transcriptomic landscape reveals the differences in cell differentiation and immune microenvironment of papillary thyroid carcinoma between genders

M Peng, G Wei, Y Zhang, H Li, Y Lai, Y Guo, Y Chen… - Cell & bioscience, 2021 - Springer
Background Papillary thyroid carcinoma (PTC) is the main pathological type of thyroid
carcinoma (TC). Gender is a prominent background parameter for patients with PTC. Here …

Single-cell and bulk RNA sequencing reveal heterogeneity and diagnostic markers in papillary thyroid carcinoma lymph-node metastasis

DN Lu, WC Zhang, YZ Lin, HY Jiang, R He… - Journal of …, 2024 - Springer
Purpose Papillary thyroid carcinoma (PTC) is characterized by lymph-node metastasis
(LNM), which affects recurrence and prognosis. This study analyzed PTC LNM by single-cell …

[HTML][HTML] Interactions between LAMP3+ dendritic cells and T-cell subpopulations promote immune evasion in papillary thyroid carcinoma

Z Wang, X Ji, Y Zhang, F Yang, H Su… - … for Immunotherapy of …, 2024 - ncbi.nlm.nih.gov
Background The incidence of papillary thyroid cancer (PTC) continues to rise all over the
world, 10–15% of the patients have a poor prognosis. Although immunotherapy has been …

Role of cytotoxic T cells and PD-1 immune checkpoint pathway in papillary thyroid carcinoma

S Banerjee, U Nahar, D Dahiya, S Mukherjee… - Frontiers in …, 2022 - frontiersin.org
Background Lymphocytic thyroiditis (LT) is frequently seen in the tumor microenvironment
(TME) of papillary thyroid carcinomas (PTCs). However, the characteristic of these tumor …

Papillary thyroid carcinoma landscape and its immunological link with hashimoto thyroiditis at single-cell resolution

J Pan, F Ye, C Yu, Q Zhu, J Li, Y Zhang… - Frontiers in Cell and …, 2021 - frontiersin.org
The tumor microenvironment heterogeneity of papillary thyroid cancer (PTC) is poorly
characterized. The relationship between PTC and Hashimoto thyroiditis (HT) is also in …

Single-cell transcriptomic analysis of ecosystems in papillary thyroid carcinoma progression

T Yan, W Qiu, H Weng, Y Fan, G Zhou… - Frontiers in …, 2021 - frontiersin.org
Background Despite extensive research, the papillary thyroid carcinoma (PTC) ecosystem is
poorly characterized and, in particular, locoregional progression. Available evidence …

Immune profiling identifies CD8+ T-cell subset signatures as prognostic markers for recurrence in papillary thyroid cancer

Z Chen, ML Guo, YY Li, K Yan, L Li, F Shen… - Frontiers in …, 2022 - frontiersin.org
Background Thyroid tissue has a special immune microenvironment that is not well
characterized. Whether immune cells have a prognostic value in the recurrence of papillary …

Single-cell transcriptome analysis reveals inter-tumor heterogeneity in bilateral papillary thyroid carcinoma

T Wang, J Shi, L Li, X Zhou, H Zhang, X Zhang… - Frontiers in …, 2022 - frontiersin.org
Background The tumor microenvironment (TME) plays a pivotal role in cancer progression in
papillary thyroid carcinoma (PTC), yet the composition and the phenotype of cells within the …