Bacterial ribosomal RNAs are synthesized by a dedicated, conserved transcription-
elongation complex that transcribes at high rates, shields RNA polymerase from premature …

Transcriptional pausing by RNA polymerases (RNAPs) is a key mechanism to regulate gene
expression in all kingdoms of life and is a prerequisite for transcription termination. The …

In Bacteria, ribosomes may bind to the nascent RNA emerging from the transcribing RNA
polymerase and initiate translation. Transcription‐translation coupling plays diverse roles in …

Construction of the eukaryotic ribosome is a complex process in which a nascent ribosomal
RNA (rRNA) emerging from RNA Polymerase I hierarchically folds into a native three …

E scherichia coli NusA and NusB proteins bind specific sites, such as those in the leader
and spacer sequences that flank the 16 S region of the ribosomal RNA transcript, forming a …

RNA folding during transcription resembles folding in a cellular environment. We previously
investigated the folding of a large ribozyme derived from a bacterial RNase P RNA during its …

Universally conserved factors from NusG family bind at the upstream fork junction of
transcription elongation complexes and modulate RNA synthesis in response to translation …

In prokaryotes, translation can occur on mRNA that is being transcribed in a process called
coupling. How the ribosome affects the RNA polymerase (RNAP) during coupling is not well …

In bacteria transcription and translation are linked in time and space. When coupled to RNA
polymerase (RNAP), the translating ribosome ensures transcriptional processivity by …

In prokaryotes, RNA polymerase and ribosomes can bind concurrently to the same RNA
transcript, leading to the functional coupling of transcription and translation. The interactions …