Recent advances in radiotherapy technology now enable us to deliver a booster dose of
radiation to small target fractions in a malignant tumor. To fully exploit this technology in …

The hypoxic condition is a common feature that negatively impacts the efficacy of radio-and
chemotherapy in solid tumors. Hypoxia-inducible factors (HIF-1, 2, 3) predominantly regulate …

Abstract Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating
radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here …

Abstract Hypoxia inducible factor-1 (HIF-1) promotes tumor cell adaptation to
microenvironmental stress. HIF-1 is up-regulated in irradiated tumors and serves as a …

Hypoxia, defined as a decrease of tissue oxygen levels, represents a fundamental
pathophysiological condition in the microenvironment of solid tumors. Tumor hypoxia is …

A large body of clinical evidence exists to suggest that tumor hypoxia negatively impacts
radiotherapy. As a result, there has been longstanding active research into novel methods of …

High levels of hypoxia inducible factor (HIF)-1α in tumors are reported to be associated with
tumor progression and resistance to therapy. To examine the impact of HIF-1α on …

Local recurrence and distant metastasis frequently occur after radiation therapy for cancer
and can be fatal. Evidence obtained from radiochemical and radiobiological studies has …

Tumor hypoxia has been attracting increasing attention in the fields of radiation biology and
oncology since Thomlinson and Gray detected hypoxic cells in malignant solid tumors and …

Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the
function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay …