Hypoxia is a commonly occurring event in solid tumours. It triggers specific and non-specific
mechanisms enabling the cell to adapt to oxygen deprivation. The most important role in this …

Hypoxia, a reduction in the normal level of tissue oxygen tension, occurs in most solid
tumors in regions where tumor growth outstrips new blood vessel formation. Hypoxic cancer …

Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a
profound impact on clinical outcomes in cancer patients. At decreased oxygen tensions …

Most solid tumors develop regions of hypoxia as they grow and outstrip their blood supply. In
order to survive in the stressful hypoxic environment, tumor cells have developed a …

Through a poorly understood mechanism, tumors respond to radiation by secreting
cytokines capable of inhibiting apoptosis in endothelial cells, thereby diminishing treatment …

Abstract Purpose: Hypoxia-inducible factor 1 (HIF-1) promotes cancer cell survival and
tumor progression. The specific role played by HIF-1 and tumor–stromal interactions toward …

The discovery of hypoxia-inducible factor-1 has led to a rapidly increasing understanding of
the molecular mechanism of tumor hypoxia in the past two decades. Today it is generally …

The hypoxic microenvironment is one of the major features of solid tumors, which regulates
cell malignancy in multiple ways. As a response to hypoxia, a large number of target genes …

We breathe air that is 21% oxygen, but some of our tissues get by on 7%, and many tumor
cells on 1% or less. Tumors cope with very low oxygen concentration, or hypoxia, in several …

Tumor progression occurs as a result of the clonal selection of cells in which somatic
mutations have activated oncogenes or inactivated tumor suppressor genes leading to …