Effect of end‐tidal CO2 clamping on cerebrovascular function, oxygenation, and performance during 15‐km time trial cycling in severe normobaric hypoxia: the role of cerebral O …

JL Fan, N Bourdillon, B Kayser - Physiological reports, 2013 - Wiley Online Library
During heavy exercise, hyperventilation‐induced hypocapnia leads to cerebral
vasoconstriction, resulting in a reduction in cerebral blood flow (CBF). A reduction in CBF …

[HTML][HTML] The Effect of Adding CO2 to Hypoxic Inspired Gas on Cerebral Blood Flow Velocity and Breathing during Incremental Exercise

JL Fan, B Kayser - PloS one, 2013 - journals.plos.org
Hypoxia increases the ventilatory response to exercise, which leads to hyperventilation-
induced hypocapnia and subsequent reduction in cerebral blood flow (CBF). We studied the …

Role of CO2 in the cerebral hyperemic response to incremental normoxic and hyperoxic exercise

KJ Smith, KW Wildfong, RL Hoiland… - Journal of Applied …, 2016 - journals.physiology.org
Cerebral blood flow (CBF) is temporally related to exercise-induced changes in partial
pressure of end-tidal carbon dioxide (PetCO2); hyperoxia is known to enhance this …

Does cerebral oxygen delivery limit incremental exercise performance?

AW Subudhi, JT Olin, AC Dimmen… - Journal of Applied …, 2011 - journals.physiology.org
Previous studies have suggested that a reduction in cerebral oxygen delivery may limit
motor drive, particularly in hypoxic conditions, where oxygen transport is impaired. We …

Hypocapnia during hypoxic exercise and its impact on cerebral oxygenation, ventilation and maximal whole body O2 uptake

C Siebenmann, H Sørensen, RA Jacobs… - Respiratory physiology …, 2013 - Elsevier
With hypoxic exposure ventilation is elevated through the hypoxic ventilatory response. We
tested the hypothesis that the resulting hypocapnia reduces maximal exercise capacity by …

CO2 supplementation dissociates cerebral oxygenation and middle cerebral artery blood velocity during maximal cycling

RK Hansen, PS Nielsen, MW Schelske… - … journal of medicine …, 2020 - Wiley Online Library
This study evaluated whether the reduction of prefrontal cortex oxygenation (ScO2) during
maximal exercise depends on the hyperventilation‐induced hypocapnic attenuation of …

Cerebral hypoperfusion during hypoxic exercise following two different hypoxic exposures: independence from changes in dynamic autoregulation and reactivity

PN Ainslie, M Hamlin, J Hellemans… - American Journal …, 2008 - journals.physiology.org
We examined the effects of exposure to 10–12 days intermittent hypercapnia [IHC: 5: 5-min
hypercapnia (inspired fraction of CO2 0.05)-to-normoxia for 90 min (n= 10)], intermittent …

Cerebral blood flow, frontal lobe oxygenation and intra-arterial blood pressure during sprint exercise in normoxia and severe acute hypoxia in humans

D Curtelin, D Morales-Alamo… - Journal of Cerebral …, 2018 - journals.sagepub.com
Cerebral blood flow (CBF) is regulated to secure brain O2 delivery while simultaneously
avoiding hyperperfusion; however, both requisites may conflict during sprint exercise. To …

Cerebral blood flow and oxygenation at maximal exercise: the effect of clamping carbon dioxide

JT Olin, AC Dimmen, AW Subudhi, RC Roach - Respiratory physiology & …, 2011 - Elsevier
During exercise, as end-tidal carbon dioxide ([Formula: see text]) drops after the respiratory
compensation point (RCP), so does cerebral blood flow velocity (CBFv) and cerebral …

Two-week normobaric intermittent-hypoxic exposures stabilize cerebral perfusion during hypocapnia and hypercapnia

P Zhang, X Shi, HF Downey - Experimental Biology and …, 2015 - journals.sagepub.com
The effect of moderately extended, intermittent-hypoxia (IH) on cerebral perfusion during
changes in CO2 was unknown. Thus, we assessed the changes in cerebral vascular …