DNA copy number analysis has been instrumental for the identification of genetic alterations
in B-cell precursor acute lymphoblastic leukemia. Notably, some of these genetic defects …

To identify copy number alterations (CNAs) in pediatric B-cell precursor acute lymphoblastic
leukemia (BCP ALL), array comparative genomic hybridization was performed on 50 cases; …

In childhood B-cell precursor acute lymphoblastic leukemia, cytogenetics is important in
diagnosis and as an indicator of response to therapy, thus playing a key role in risk …

Background Recent genetic studies using high-throughput sequencing have substantially
revealed genetic alterations in pediatric patients with B-progenitor acute lymphoblastic …

To resolve the genetic heterogeneity within pediatric high-risk B-precursor acute
lymphoblastic leukemia (ALL), a clinically defined poor-risk group with few known recurring …

Over the last 50 years, while significant advances have been made in the successful
treatment of childhood leukaemia, similar progress has been made in understanding the …

Acute lymphoblastic leukaemia (ALL) occurs at all ages but is the most common cancer of
childhood. The current treatment of paediatric ALL is highly successful with up to 90 …

Pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is associated with a high
frequency of copy number alterations (CNAs) in IKZF1, EBF1, PAX5, CDKN2A/B, RB1 …

Copy number alterations (CNAs) in genes committed to B-cell precursors have been
associated with poor survival in subgroups of patients with B-cell precursor acute …

The recently proposed molecular genetic criteria promise improved risk-prediction in B-cell
acute lymphoblastic leukemia (B-ALL). This study assesses their utility in BCR-ABL1 …