Background Cryptococcus neoformans is an encapsulated yeast that is a facultative
intracellular pathogen. The interaction between macrophages and C. neoformans is critical …

Background The interaction between macrophages and Cryptococcus neoformans (Cn) is
critical for containing dissemination of this pathogenic yeast. However, Cn can either lyse …

To produce chronic infection, microbial pathogens must escape host immune defenses.
Infection with the human pathogenic fungus Cryptococcus neoformans is typically chronic …

Cryptococcus neoformans (Cn) is an encapsulated yeast that is a facultative intracellular
pathogen and a frequent cause of human disease. The interaction of Cn with alveolar …

The ability of fungi to transition between unicellular and multicellular growth has a profound
impact on our health and the economy. Many important fungal pathogens of humans …

presented compelling in vitro and in vivo evidence that the encapsulated fungus
Cryptococcus neoformans is a facultative intracellular parasite of macrophages …

Cryptococcus neoformans (CN), an encapsulated, ubiquitous environmental yeast, is
pathogenic for humans, primarily those with compromised immune function. CN is believed …

Upon ingestion by macrophages, Cryptococcus neoformans can survive and replicate
intracellularly unless the macrophages become classically activated. The mechanism …

Cryptococcus neoformans is a lethal fungus disguised in a polysaccharide coat. It can
remain dormant in the host for decades prior to reactivation, causing systemic …

ABSTRACT A unique aspect of the interaction of the fungus Cryptococcus neoformans with
macrophages is the phenomenon of nonlytic exocytosis, also referred to as “vomocytosis” or …