Tumors require a blood supply for growth and hematogenous dissemination. Much attention
has been focused on the role of angiogenesis—the recruitment of new vessels into a tumor …

Tissue sections from aggressive human intraocular (uveal) and metastatic cutaneous
melanomas generally lack evidence of significant necrosis and contain patterned networks …

In 1999, The American Journal of Pathology published an article entitled “Vascular Channel
Formation by Human Melanoma Cells in Vivo and in Vitro: Vasculogenic Mimicry,” by …

The term vasculogenic mimicry describes the formation of fluid‐conducting channels by
highly invasive and genetically dysregulated tumor cells. Two distinctive types of …

Abstract In 1999, the American Journal of Pathology published an article, entitled “Vascular
channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry” by …

Tumors require a blood supply to sustain growth and to metastasize. 1 They initially co-opt
existing vessels to survive and grow, 2 but the concept that they eventually send signals for …

The gene-expression profile of aggressive cutaneous and uveal melanoma cells resembles
that of an undifferentiated, embryonic-like cell. The plasticity of certain types of cancer cell …

In 1999, Maniotis reported that blood vessels of highly aggressive uveal melanomas are
formed by tumor cells instead of endothelial cells. He termed this novel concept in tumor …

In a recent publication, Maniotis et al1 report that blood vessels of malignant eye tumors
known as uveal melanomas are formed by tumor cells instead of endothelial cells. The …

Vasculogenic mimicry (VM) describes the process utilized by highly aggressive cancer cells
to generate vascular-like structures without the presence of endothelial cells. VM has been …