This review discusses the application of time-of-flight secondary ion mass spectrometry (TOF-
SIMS) and magnetic sector SIMS with high lateral resolution performed on a Cameca …

Fundamental advances in secondary ion mass spectrometry (SIMS) now allow for the
examination and characterization of lipids directly from biological materials. The successful …

Lipids are an important class of biomolecules with many roles within cells and tissue. As
targets for study, they present several challenges. They are difficult to label, as many labels …

Secondary ion mass spectrometry (SIMS) has been in use in biomedical imaging for more
than three decades and has resulted in some important biomedical discoveries. However …

This brief article provides an overview of the current state of the art in biological imaging
mass spectrometry using cluster time-of-flight secondary ion mass spectrometry (TOF …

Over the past few decades, several approaches have been used to image lipids in cells and
tissues, but most have limited spatial resolution and sensitivity. Here, we discuss a relatively …

Mass spectrometric imaging is a powerful tool to interrogate biological complexity. One such
technique, time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging, has been …

Lipids are abundant biomolecules performing central roles to maintain proper functioning of
cells and biological bodies. Due to their highly complex composition, it is critical to obtain …

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) is a well-established
bioanalytical method for directly imaging the chemical distribution across single cells. Here …

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) can be utilized to map the
distribution of various molecules on a surface with submicrometer resolution. Much of its …