Ochratoxin A carcinogenicity involves a complex network of epigenetic mechanisms

M Marin-Kuan, C Cavin, T Delatour, B Schilter - Toxicon, 2008 - Elsevier
Ochratoxin A (OTA) is a mycotoxin occurring in a wide range of food products. Because of
the limitation of human epidemiological data, the safety significance of OTA in food has to …

Ochratoxin A: potential epigenetic mechanisms of toxicity and carcinogenicity

B Schilter, M Marin-Kuan, T Delatour… - Food additives and …, 2005 - Taylor & Francis
Assessment of the significance to human health of ochratoxin A (OTA) in food is limited by a
lack of human toxicity data. Therefore, OTA risk evaluation relies mainly on the use of animal …

A toxicogenomics approach to identify new plausible epigenetic mechanisms of ochratoxin a carcinogenicity in rat

M Marin-Kuan, S Nestler, C Verguet… - Toxicological …, 2006 - academic.oup.com
Ochratoxin A (OTA) is a mycotoxin occurring naturally in a wide range of food commodities.
In animals, it has been shown to cause a variety of adverse effects, nephrocarcinogenicity …

In vitro gene expression data supporting a DNA non-reactive genotoxic mechanism for ochratoxin A

L Arbillaga, A Azqueta, JHM van Delft… - Toxicology and Applied …, 2007 - Elsevier
Ochratoxin A (OTA) is a mycotoxin often found in cereals and agricultural products. There is
unequivocal evidence of renal carcinogenicity of OTA in male rats, although the mechanism …

[HTML][HTML] Ochratoxin A: 50 years of research

F Malir, V Ostry, A Pfohl-Leszkowicz, J Malir, J Toman - Toxins, 2016 - mdpi.com
Since ochratoxin A (OTA) was discovered, it has been ubiquitous as a natural contaminant
of moldy food and feed. The multiple toxic effects of OTA are a real threat for human beings …

In vitro cytogenetic results supporting a DNA nonreactive mechanism for ochratoxin A, potentially relevant for its carcinogenicity

P Mosesso, S Cinelli, R Bellacima… - Chemical research in …, 2008 - ACS Publications
Ochratoxin A (OTA) is a widespread mycotoxin of cereals and many agricultural products
and causes high incidences of renal tumors in rodents. Although its carcinogenic properties …

Ochratoxin A-induced mutagenesis in mammalian cells is consistent with the production of oxidative stress

N Palma, S Cinelli, O Sapora, SH Wilson… - Chemical research in …, 2007 - ACS Publications
Ochratoxin A (OTA) is a widespread mycotoxin in food and a powerful nephrocarcinogen in
rats. The mutagenicity of OTA has been extensively investigated but with conflicting results …

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans

A Pfohl‐Leszkowicz… - Molecular nutrition & food …, 2007 - Wiley Online Library
Ochratoxin A (OTA) is a ubiquitous mycotoxin produced by fungi of improperly stored food
products. OTA is nephrotoxic and is suspected of being the main etiological agent …

Toxicokinetics and toxicodynamics of ochratoxin A, an update

D Ringot, A Chango, YJ Schneider… - Chemico-biological …, 2006 - Elsevier
Ochratoxin A (OTA) is a mycotoxin produced by fungi of two genera: Penicillium and
Aspergillus. OTA has been shown to be nephrotoxic, hepatotoxic, teratogenic and …

An update on direct genotoxicity as a molecular mechanism of ochratoxin a carcinogenicity

A Pfohl-Leszkowicz, RA Manderville - Chemical research in …, 2012 - ACS Publications
Ochratoxin A (OTA) is a naturally occurring chlorophenolic fungal toxin that contaminates a
wide range of food products and poses a cancer threat to humans. The mechanism of action …