Familial hypercholesterolemia (FH) is an oligogenic disorder characterized by markedly
elevated low-density lipoprotein cholesterol (LDLC) levels. Variants in four genes have been …

Abstract Purpose of Review Familial hypercholesterolaemia (FH) is an inherited disorder of
low-density lipoprotein cholesterol (LDL-C) which is characterised by a raised cholesterol …

Familial hypercholesterolemia (FH) is one of the most common monogenic diseases,
leading to an increased risk of premature atherosclerosis and its cardiovascular …

Background: A pathogenic variant in LDLR, APOB, or PCSK9 can be identified in 30% to
80% of patients with clinically-diagnosed familial hypercholesterolemia (FH). Alternatively,∼ …

Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated low-
density lipoprotein (LDL) cholesterol and premature cardiovascular disease, with a …

Background Familial hypercholesterolaemia (FH) is an autosomal dominant disease of lipid
metabolism, which leads to early coronary heart disease. Mutations in LDLR, APOB and …

Purpose Familial hypercholesterolemia (FH) is an autosomal disorder of lipid metabolism
presenting with increased cardiovascular risk. Although more than 1,700 variants have been …

Familial hypercholesterolemia (FH) is an autosomal dominant disorder associated with
premature cardiovascular disease (CVD). Mutations in the LDLR, APOB, and PCSK9 genes …

Background and aims Autosomal-dominant familial hypercholesterolemia (FH) is
characterized by elevated plasma levels of low-density lipoprotein cholesterol (LDL-C) and …

Familial hypercholesterolemia (FH) is a genetic disorder with an increased risk of early-
onset coronary artery disease. Although some clinically diagnosed FH cases are caused by …