A DMAP catalyzed synthesis of new 4-benzyloxy-and 4-aryloxy-2-
trichloromethylquinazolines was studied, in a view to react 4-chloroquinazolines with poorly …

A series of original 4-aryl-substituted 2-trichloromethylquinazoline derivatives was
synthesized using a microwave-assisted Suzuki-Miyaura cross-coupling approach …

To identify a new safe antiplasmodial molecular scaffold, an original series of 2-
trichloromethylquinazolines, functionalized in position 4 by an alkyl-or arylamino substituent …

From the promising results we previously obtained in quinazoline series and to complete the
evaluation of the in vitro antiplasmodial activity of original 2-trichloromethylquinazolines, we …

The multistep synthesis of new quinazoline-derived molecules and their in vitro
antiplasmodial evaluation on the W2 chloroquino-resistant Plasmodium falciparum strain is …

Thanks to a preliminary in vitro screening of several CCl 3-substituted-nitrogen containing
heterocycles belonging to our chemical library, the 2-trichloromethylquinoxaline scaffold …

The synthesis and in vitro evaluation of novel triazole-linked chloroquinoline derivatives as
potential antiplasmodial agents against Plasmodium falciparum is reported. The 15 …

Several classes of antimalarial drugs are currently available, although issues of toxicity and
the emergence of drug resistant malaria parasites have reduced their overall therapeutic …

Abstract Treatment of 4-hydroxyquinolines with (2-methyl) allyl bromide in the presence of K
2 CO 3 resulted in the formation of novel N-[(2-methyl) allyl]-4-quinolones through selective …

Aminoquinolines have recently been indicated to be an important class of chemotherapeutic
agents for artemisinin‐based antimalarial combination therapy. A rapid, cheap, possibly …