Bone defects and diseases are devastating, and can lead to severe functional deficits or
even permanent disability. Nevertheless, orthopedic implants and scaffolds can facilitate the …

Repair of critical size bone defects is a clinical challenge that usually necessitates the use of
bone substitutes. For successful bone repair, the substitute should possess osteoconductive …

Studies related to biomaterials that stimulate the repair of living tissue have increased
considerably, improving the quality of many people's lives that require surgery due to …

The use of bone grafts is the standard to treat skeletal fractures, or to replace and regenerate
lost bone, as demonstrated by the large number of bone graft procedures performed …

Zinc is a micronutrient of key importance for human health. An increasing number of studies
indicate that zinc plays a significant role in bone tissue's normal development and …

Abstract Type I collagen (Col I) is a main component of extracellular matrix (ECM). Its safety,
biocompatibility, hydrophilicity and pyrogen immunogenicity make it suitable for tissues …

Bone is a regenerative organ characterized by self-renewal ability. Indeed, it is a very
dynamic tissue subjected to continuous remodeling in order to preserve its structure and …

Zinc-incorporated biomaterials show promoting effects on osteogenesis; however, excessive
zinc ions lead to cytotoxic reactions and also have other adverse effects. Therefore, the …

Tissue is vital to the organization of multicellular organisms, because it creates the different
organs and provides the main scaffold for body shape. The quest for effective methods to …

Although engineered nanoparticles loaded with specific growth factors are used to regulate
differentiation of stem cells, the low loading efficiency and biocompatibility are still great …