Magnesium ions promote the biological behaviour of rat calvarial osteoblasts by activating the PI3K/Akt signalling pathway

J Wang, XY Ma, YF Feng, ZS Ma, TC Ma… - Biological trace element …, 2017 - Springer
Magnesium has been investigated as a biodegradable metallic material. Increased
concentrations of Mg 2+ around magnesium implants due to biodegradation contribute to its …

Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

N Baheiraei, H Eyni, B Bakhshi, R Najafloo… - Scientific Reports, 2021 - nature.com
Bioactive glasses (BGs) have attracted added attention in the structure of the scaffolds for
bone repair applications. Different metal ions could be doped in BGs to induce specific …

A Bi‐lineage conducive scaffold for osteochondral defect regeneration

Y Wu, S Zhu, C Wu, P Lu, C Hu, S Xiong… - Advanced Functional …, 2014 - Wiley Online Library
Because cartilage and bone tissues have different lineage‐specific biological properties, it is
challenging to fabricate a single type of scaffold that can biologically fulfill the requirements …

[HTML][HTML] Magnesium-based biomaterials as emerging agents for bone repair and regeneration: From mechanism to application

H Zhou, B Liang, H Jiang, Z Deng, K Yu - Journal of Magnesium and Alloys, 2021 - Elsevier
Magnesium (Mg) is the fourth most abundant element in the human body and is important in
terms of specific osteogenesis functions. Here, we provide a comprehensive review of the …

[HTML][HTML] Therapeutically relevant aspects in bone repair and regeneration

RA Perez, SJ Seo, JE Won, EJ Lee, JH Jang… - Materials Today, 2015 - Elsevier
Over the past few years, attention has been focused on the therapeutic roles in designing
bone scaffolds for successful repair and regeneration. Indeed, biologically dynamic events …

Bone tissue engineering scaffold materials: Fundamentals, advances, and challenges

C Xu, Z Liu, X Chen, Y Gao, W Wang, X Zhuang… - Chinese Chemical …, 2023 - Elsevier
Bone damage caused by trauma and tumors is a serious problem for human health,
therefore, three-dimensional (3D) scaffolding materials that stimulate and promote the …

Biological roles and delivery strategies for ions to promote osteogenic induction

E Bosch-Rué, L Diez-Tercero… - Frontiers in cell and …, 2021 - frontiersin.org
Bone is the most studied tissue in the field of tissue regeneration. Even though it has intrinsic
capability to regenerate upon injury, several pathologies and injuries could hamper the …

Integrating silicon/zinc dual elements with PLGA microspheres in calcium phosphate cement scaffolds synergistically enhances bone regeneration

W Liang, M Gao, J Lou, Y Bai, J Zhang, T Lu… - Journal of materials …, 2020 - pubs.rsc.org
Integrating multiple pro-osteogenic factors into bone graft substitutes is a practical and
effective approach to improve bone repair efficacy. Here, Si–Zn dual elements and PLGA …

Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair

R Agarwal, AJ García - Advanced drug delivery reviews, 2015 - Elsevier
Bone tissue has a remarkable ability to regenerate and heal itself. However, large bone
defects and complex fractures still present a significant challenge to the medical community …

Magnesium Chloride promotes Osteogenesis through Notch signaling activation and expansion of Mesenchymal Stem Cells

JM Díaz-Tocados, C Herencia, JM Martínez-Moreno… - Scientific reports, 2017 - nature.com
Mesenchymal stem cells (MSC) are osteoblasts progenitors and a variety of studies suggest
that they may play an important role for the health in the field of bone regeneration …