A coordinated interaction between osteogenesis and osteoimmune microenvironment is
essential for successful bone healing. In particular, macrophages play a central regulatory …

Metal ions are important trace elements in the human body, which directly affect the human
metabolism and the regeneration of damaged tissues. For instance, the advanced …

Despite its intrinsic ability to regenerate form and function after injury, bone tissue can be
challenged by a multitude of pathological conditions. While innovative approaches have …

Biomedical applications of nanomaterials are exponentially increasing every year due to
analogy to various cell receptors, ligands, structural proteins, and genetic materials (that is …

Large injuries to bones are still one of the most challenging musculoskeletal problems.
Tissue engineering can combine stem cells, scaffold biomaterials, and biofactors to aid in …

The healing of critical-sized bone defects (CSD) remains a challenge in orthopedic
medicine. In recent years, scaffolds with sophisticated microstructures fabricated by the …

Mineralized biomaterials have been demonstrated to enhance bone regeneration compared
to their non-mineralized analogs. As non-mineralized scaffolds do not perform as well as …

In the process of bone tissue engineering, the osteoimmunomodulatory property of
biomaterials is very important for osteogenic differentiation of stem cells, which determines …

Abstract Three-dimensional (3D) porous zinc (Zn) with a moderate degradation rate is a
promising candidate for biodegradable bone scaffolds. However, fabrication of such …

Additively manufacturing (AM) opens up the possibility for biodegradable metals to possess
uniquely combined characteristics that are desired for bone substitution, including bone …