Understanding aspects of Aluminum exposure in a lzheimer's disease development

R Kandimalla, J Vallamkondu, EB Corgiat… - Brain …, 2016 - Wiley Online Library
Aluminum is a ubiquitously abundant nonessential element. Aluminum has been associated
with neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral …

The role of aluminum in neurotoxic and neurodegenerative processes

T Kiss, K Gajda‐Schrantz… - … diseases and metal ions, 2006 - Wiley Online Library
Aluminum derives its name from the Latin alumen (bitter salt), KAlSO4 2· 12H2O. This was
used as an astringent in ancient medicine in Greece and later in Rome. Al is the most …

Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders

J Lemire, VD Appanna - Journal of Inorganic Biochemistry, 2011 - Elsevier
Aluminum (Al) has been implicated in a variety of neurological diseases. However, the
molecular mechanisms that enable Al to be involved in these disorders have yet to be fully …

Aluminum: impacts and disease

P Nayak - Environmental research, 2002 - Elsevier
Aluminum is the most widely distributed metal in the environment and is extensively used in
modern daily life. Aluminum enters into the body from the environment and from diet and …

Intraventricular administration of the cholinotoxin AF64A increases the accumulation of aluminum in the rat parietal cortex and hippocampus, but not in the frontal …

P Szerdahelyi, P Kása - Brain research, 1988 - Elsevier
Aluminum (Al) concentrations of the rat frontal cortex, parietal cortex, and hippocampus were
measured by atomic absorption spectroscopy 16 days after a unilateral …

Brain-derived neurotrophic factor protects cultured rat hippocampal neurons from aluminum maltolate neurotoxicity

M Kawahara, M Kato-Negishi, R Hosoda… - Journal of Inorganic …, 2003 - Elsevier
Aluminum is environmentally abundant but not an essential trace element. Although there is
increasing evidence suggesting the implication of aluminum in the pathogenesis of …

Aluminum exposure at human dietary levels for 60 days reaches a threshold sufficient to promote memory impairment in rats

CS Martinez, CDC Alterman, FM Peçanha… - Neurotoxicity …, 2017 - Springer
Aluminum (Al) is a significant environmental contaminant. While a good deal of research has
been conducted on the acute neurotoxic effects of Al, little is known about the effects of …

Aluminum toxicity and oxidative stress

RM Fernandes, LG Eiró, V dos Santos Chemelo… - Toxicology, 2021 - Elsevier
Aluminum is present in everyday life in several ways since it has high strength, ductility, and
ability to conduct energy and heat. This metal is the third most abundant in the earth's crust …

Disturbance of intracellular calcium homeostasis and CaMKII/CREB signaling is associated with learning and memory impairments induced by chronic aluminum …

B Wang, J Zhao, M Yu, X Meng, X Cui, Y Zhao… - Neurotoxicity …, 2014 - Springer
Aluminum-induced neuronal injury has been implicated in various neurodegenerative
disorders. However, the underlying mechanism involved in this pathogenesis still remains …

Aluminium-induced impairment of Ca2+ modulatory action on GABA transport in brain cortex nerve terminals

JM Cordeiro, VS Silva, CR Oliveira… - Journal of Inorganic …, 2003 - Elsevier
The γ-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in vertebrate CNS.
At GABAergic synapses, a high-affinity transporter exists, which is responsible for GABA …