Targeted therapy for NSCLC–a double-edged sword?

WCM Dempke - Anticancer Research, 2015 - ar.iiarjournals.org
Advanced or metastatic non-small cell lung cancer (NSCLC) is characterised by a poor
prognosis and few second-or third-line treatments. First-generation epidermal growth factor …

Targeted therapies for treatment of non‐small cell lung cancer—recent advances and future perspectives

J Minguet, KH Smith, P Bramlage - International journal of …, 2016 - Wiley Online Library
Non‐small cell lung cancer (NSCLC) is one of the most deadly cancers worldwide, with poor
prognosis once the disease has progressed past the point at which surgery is a viable …

Overcoming resistance to targeted therapies in NSCLC: current approaches and clinical application

P Maione, PC Sacco, A Sgambato… - … in medical oncology, 2015 - journals.sagepub.com
The discovery that a number of aberrant tumorigenic processes and signal transduction
pathways are mediated by druggable protein kinases has led to a revolutionary change in …

Management of advanced non-small cell lung cancers with known mutations or rearrangements: latest evidence and treatment approaches

M Shea, DB Costa… - Therapeutic advances in …, 2016 - journals.sagepub.com
Precision oncology is now the evidence-based standard of care for the management of
many advanced non-small cell lung cancers (NSCLCs). Expert consensus has defined …

EGFR and KRAS Mutations, and ALK Fusions: Current Developments and Personalized Therapies for Patients with Advanced Non-Small-Cell Lung Cancer

RA De Mello, P Madureira, LS Carvalho… - …, 2013 - Taylor & Francis
Personalized therapy has significantly developed in lung cancer treatment over recent
years. VEGF and EGF play a major role in non-small-cell lung cancer (NSCLC) tumor …

[PDF][PDF] Current status of targeted therapy in non-small cell lung cancer

DV Parums - Drugs Today (Barc), 2014 - academia.edu
Tumor tissue biomarkers are the basis for targeted therapy in non-small cell lung cancer
(NSCLC). These biomarkers either reflect the target of the specific drug or some factor that …

[PDF][PDF] Advances in Targeted Therapy Against Driver Mutations and Epigenetic Alterations in Non-Small Cell Lung Cancer.

J Shi, Y Chen, C Peng, L Kuang, Z Zhang… - … (Tech Science Press), 2022 - researchgate.net
The incidence and mortality of lung cancer rank top three of all cancers worldwide.
Accounting for 85% of the total number of lung cancer, non-small cell lung cancer (NSCLC) …

Current therapeutic strategies and challenges in NSCLC treatment: A comprehensive review

M Kumar, A Sarkar - Experimental oncology, 2022 - exp-oncology.com.ua
Non-small cell lung cancer (NSCLC) is one of the most lethal malignancies accountings for
nearly 80% of all lung cancer cases diagnosed and causing over one million deaths …

New target therapies in advanced non-small cell lung cancer: a review of the literature and future perspectives

RA De Mello, NM Neves, H Tadokoro… - Journal of clinical …, 2020 - mdpi.com
Introduction: Lung cancer (LC) is the most common neoplasm worldwide, and 85% of these
tumors are classified as non-small cell lung cancer (NSCLC). LC treatment was initially …

Molecular targeted therapy in the treatment of advanced stage non‐small cell lung cancer (NSCLC)

N Barr Kumarakulasinghe, N Zanwijk, RA Soo - Respirology, 2015 - Wiley Online Library
Historically, patients with advanced stage non‐small cell lung cancer (NSCLC) were treated
with chemotherapy alone, but a therapeutic plateau has been reached. Advances in the …