Background Cycling hypoxia is a well-recognized phenomenon within animal and human
solid tumors. It contributes to the resistance to cytotoxic therapies through anti-apoptotic …

Tumor cycling hypoxia is now a well-recognized phenomenon in animal and human solid
tumors. However, how tumor cycling hypoxia impacts chemotherapy is unclear. In the …

Hypoxia, which is common during tumor progression, plays important roles in tumor biology.
Failure in cell death in response to hypoxia contributes to progression and metastasis of …

Glioblastoma multiforme (GBM) tumors are the most common type of brain tumors and
resistance to radiotherapy. This study aimed to investigate the differential effect and …

Hypoxia plays an important role in the resistance of tumour cells to chemotherapy. However,
the exact mechanisms underlying this process are not well understood. Moreover, according …

Tumor microenvironment (TME), which is characterized by hypoxia, widely exists in solid
tumors. As a current research hotspot in the TME, hypoxia is expected to become a key …

Hypoxia, as an important hallmark of the tumor microenvironment, is a major cause of
oxidative stress and plays a central role in various malignant tumors, including glioblastoma …

Microenvironmental hypoxia‐mediated drug resistance is responsible for the failure of
cancer therapy. To date, the role of the hedgehog pathway in resistance to temozolomide …

Background Cycling and chronic tumor hypoxia are involved in tumor development and
growth. However, the impact of cycling hypoxia and its molecular mechanism on …

Aim Clinical resistance is a complex phenomenon in major human cancers involving
multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular …