Osteoarthritis (OA) is a major cause of disability in the adult population. As a progressive
degenerative joint disorder, OA is characterized by cartilage damage, changes in the …

These findings have an immediate implication for research because new tools need to be
developed to study the subchondral bone–cartilage functional unit. Moreover, it could lead …

Osteoarthritis is a whole joint disease characterised by the disappearance of the cartilage
associated with subchondral bone sclerosis, formation of osteophytes and a mild …

Osteoarthritis (OA) is considered to be a complex illness in which the tissues of the joint play
a significant role in the initiation and/or progression of the pathophysiology. We still do not …

Despite increasing evidence that subchondral bone contributes to osteoarthritis (OA)
pathogenesis, little is known about local changes in bone structure compared to cartilage …

Osteoarthritis (OA) is a disease that involves the entire joint, but its pathophysiology is not
well described. Alterations in peri-articular bone are an integral part of the OA disease …

Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been
considered as primarily a disease of the articular cartilage, the participation of subchondral …

Introduction Osteoporosis (OP) increases cartilage damage in a combined rabbit model of
OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at …

Osteoarthritis (OA) is a major cause of pain and disability in the aging population, but its
pathogenesis remains incompletely understood. Alterations beneath the articular cartilage at …

The classical view of the pathogenesis of osteoarthritis (OA) is that subchondral sclerosis is
associated with, and perhaps causes, age-related joint degeneration. Recent observations …