Polymorphonuclear leukocytes (PMNs) release the contents of granules during their
migration to inflammatory sites. On liberation from the first leukocyte to enter injured tissue …

Neutrophil granulocytes form the first line of host defense against invading pathogens and
tissue injury. They are rapidly recruited from the blood to the affected sites, where they …

In acute inflammation, infiltrating polymorphonuclear leukocytes (also known as PMNs)
release preformed granule proteins having multitudinous effects on the surrounding …

Polymorphonuclear leukocytes (PMN) contribute to bacterial clearance by uptake and
intracellular killing of microbes. However, antimicrobial polypeptides are released …

Macrophages represent a multi-functional cell type in innate immunity that contributes to
bacterial clearance by recognition, phagocytosis and killing. In acute inflammation …

During their journey from the blood stream to sites of inflammation polymorphonuclear
leukocytes (PMN) release a wide panoply of granule proteins. Shortly after the PMN efflux …

The neutrophil is a major effector cell of innate immunity. Exocytosis of granules and
secretory vesicles plays a pivotal role in most neutrophil functions from early activation to the …

Neutrophils, the most abundant white blood cells in human circulation, entertain intense
interactions with other leukocyte subsets, platelets, and stromal cells. Molecularly, such …

Neutrophils are part of a family of granulocytes that, together with eosinophils and basophils,
play an essential role in innate immunity. Neutrophils are the most abundant circulating …

Gene expression profiling has revealed that circulating neutrophils rest between two major
bursts of transcriptional and protein synthetic activities. The first occurs in the bone marrow …