The protein tyrosine phosphatase SHP2 encoded by PTPN11 is a promising therapeutic
target for cancer therapy, while the multifaceted roles of SHP2 complicate the drug discovery …

The protein tyrosine phosphatase SHP2 encoded by PTPN11 is a promising therapeutic
target for cancer therapy. The dynamic change of SHP2 between closed and open …

Phosphorylation is a reversible post-translational modification regulated by phosphorylase
and dephosphorylase to mediate important cellular events. Src homology-2-containing …

Abstract Src homology 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2), encoded
by PTPN11, regulates cell proliferation, differentiation, apoptosis and survival via releasing …

Encoded by PTPN11, the SHP2 (Src homology-2 domain-containing protein tyrosine
phosphatase-2) is widely recognized as a carcinogenic phosphatase. As a promising anti …

Activating mutations in PTPN11 (encoding SHP2), a protein tyrosine phosphatase (PTP) that
plays an overall positive role in growth factor and cytokine signaling, are directly associated …

SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene
involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also …

Protein tyrosine phosphatases have been the focus of considerable research efforts aimed
at developing novel therapeutics; however, these targets are often characterized as being …

The protein phosphatase SHP2/PTPN11 has been reported to be a key modulator of
proliferative pathways in a wide range of malignancies. Intriguingly, SHP2 has also been …

Src homology 2 domain-containing phosphatase 2 (SHP2) is an attractive therapeutic target
for human cancers and other human diseases. Herein, we report our discovery of potent …