[HTML][HTML] Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer
A Zaravinos, C Roufas, M Nagara… - Journal of Experimental …, 2019 - Springer
Background Microsatellite unstable colorectal cancers (MSI+ CRCs) expressing PD-L1,
respond to anti-PD-1 or anti-PD-L1 checkpoint blockade, whereas microsatellite-stable …
respond to anti-PD-1 or anti-PD-L1 checkpoint blockade, whereas microsatellite-stable …
Clinical significance of programmed cell death‐ligand 1 expression and the immune microenvironment at the invasive front of colorectal cancers with high …
S Korehisa, E Oki, M Iimori, Y Nakaji… - … journal of cancer, 2018 - Wiley Online Library
Immunotherapy is reportedly effective in colorectal cancers (CRCs) with high microsatellite
instability (MSI‐H); however, the specific cell types that respond to immune checkpoint …
instability (MSI‐H); however, the specific cell types that respond to immune checkpoint …
[HTML][HTML] Beyond microsatellite testing: assessment of tumor mutational burden identifies subsets of colorectal cancer who may respond to immune checkpoint …
DA Fabrizio, TJ George Jr, RF Dunne… - Journal of …, 2018 - ncbi.nlm.nih.gov
Background The clinical application of PD1/PD-L1 targeting checkpoint inhibitors in
colorectal cancer (CRC) has largely focused on a subset of microsatellite instable (MSI-high) …
colorectal cancer (CRC) has largely focused on a subset of microsatellite instable (MSI-high) …
[HTML][HTML] Relationships between immune landscapes, genetic subtypes and responses to immunotherapy in colorectal cancer
E Picard, CP Verschoor, GW Ma… - Frontiers in …, 2020 - frontiersin.org
Colorectal cancer (CRC) is highly heterogeneous at the genetic and molecular level, which
has major repercussions on the efficacy of immunotherapy. A small subset of CRCs exhibit …
has major repercussions on the efficacy of immunotherapy. A small subset of CRCs exhibit …
[HTML][HTML] Immune profiling of microsatellite instability-high and polymerase ε (POLE)-mutated metastatic colorectal tumors identifies predictors of response to anti-PD-1 …
C Wang, J Gong, TY Tu, PP Lee… - Journal of gastrointestinal …, 2018 - ncbi.nlm.nih.gov
Background Microsatellite instability-high (MSI-H) and polymerase ε (POLE)-mutated
metastatic colorectal cancer (mCRC) represent hypermutated and ultramutated tumor …
metastatic colorectal cancer (mCRC) represent hypermutated and ultramutated tumor …
The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy
Y Xiao, GJ Freeman - Cancer discovery, 2015 - AACR
The microsatellite instable (MSI) subset of colorectal cancer exhibits an active Th1/CTL
immune microenvironment, probably due to recognition of a high number of tumor …
immune microenvironment, probably due to recognition of a high number of tumor …
[HTML][HTML] Inflammation promotes resistance to immune checkpoint inhibitors in high microsatellite instability colorectal cancer
Q Sui, X Zhang, C Chen, J Tang, J Yu, W Li… - Nature …, 2022 - nature.com
Inflammation is a common medical complication in colorectal cancer (CRC) patients, which
plays significant roles in tumor progression and immunosuppression. However, the …
plays significant roles in tumor progression and immunosuppression. However, the …
[HTML][HTML] PD-L1 targeting and subclonal immune escape mediated by PD-L1 mutations in metastatic colorectal cancer
A Stein, D Simnica, C Schultheiß, R Scholz… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background In patients with microsatellite stable (MSS) metastatic colorectal cancer
(mCRC), immune checkpoint blockade is ineffective, and combinatorial approaches …
(mCRC), immune checkpoint blockade is ineffective, and combinatorial approaches …
[HTML][HTML] Immune overdrive signature in colorectal tumor subset predicts poor clinical outcome
The prognostic value of immune cell infiltration within the tumor microenvironment (TME)
has been extensively investigated via histological and genomic approaches. Based on the …
has been extensively investigated via histological and genomic approaches. Based on the …
Targeting PD-L1 and TIGIT could restore intratumoral CD8 T cell function in human colorectal cancer
M Thibaudin, E Limagne, L Hampe, E Ballot… - Cancer Immunology …, 2022 - Springer
Microsatellite stable colorectal cancers (MSS-CRC) are resistant to anti-PD-1/PD-L1 therapy
but the combination of immune checkpoints inhibitors (ICI) could be a clue to reverse …
but the combination of immune checkpoints inhibitors (ICI) could be a clue to reverse …
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