Cardiovascular diseases (CVDs) have been the leading cause of mortality in the United
States since 1975. Owing to the pervasive nature of risk factors such as contemporary high …

GPR35 (G-protein–coupled receptor 35) is a poorly characterized receptor that has
garnered increased interest as a therapeutic target through its implications in a range of …

In 1997, the orphan G protein-coupled receptor 30, GPR30 was cloned using human
umbilical vein endothelial cells (HUVECs) exposed to fluid shear stress (FSS), one of the …

In BRIef Page 1 www.nature.com/nrcardio Deficiency in the orphan G proteincoupled receptor
146 (GPR146) decreases blood lipid levels and protects against atherosclerosis in mice …

Here, we outline and deliberate on recent progress focused on: enhancing comprehension
of the effects of inhibiting GPR146 in humans through genetic instruments, evaluating the …

Background/Aims: Endothelial cell dysfunction is the principal pathological process
underlying atherosclerotic cardiovascular disease. G protein-coupled receptor 124 …

Vascular smooth muscle cell (VSMC) migration and proliferation is central to neointima
formation in vein graft failure following coronary artery bypass. However, there are currently …

The TCA cycle intermediate metabolite 'succinate'has been proposed as an inflammatory
mediator, influencing autoimmunity and allergic reactions, through ligation to its sensing …

Atherosclerosis is a chronic and multifactorial disease accompanied by an imbalance
between resolving and pro-inflammatory lipid mediators. Targeting lipid signaling might offer …

G protein-coupled receptor 35 (GPR35) is an orphan receptor, discovered in 1998, that has
garnered interest as a potential therapeutic target through its association with a range of …