Background: In mice, GPR146 (G-protein–coupled receptor 146) deficiency reduces plasma
lipids and protects against atherosclerosis. Whether these findings translate to humans is …

GPR84 is an orphan G-protein coupled receptor, expressed on monocytes, macrophages
and neutrophils and is significantly upregulated by inflammatory stimuli. The physiological …

BACKGROUND The orphan receptor G protein–coupled receptor 35 (GPR35) has been
associated with a range of diseases, including cancer, inflammatory bowel disease …

Metabolic syndrome increases the risk of stroke, cardiovascular disease, and diabetes. The
morbidity and mortality associated with this constellation of risk factors are equally alarming …

GPR35 is a class A, rhodopsin-like G protein-coupled receptor (GPCR) first identified more
than 20 years ago. In the intervening period, identification of strong expression in the lower …

Attachment of monocytes to endothelial cells is a major event in the pathogenesis of
atherosclerosis and cardiovascular disease. As atherosclerosis is considered to be an …

G-protein-coupled receptors (GPCRs) transduce signals via heterotrimeric G-proteins/β-
arrestin and are the most common targets for currently approved drugs. Well-defined ligands …

The G protein-coupled receptor (GPCR) superfamily is the largest known receptor family in
the human genome. Although the family of adhesion GPCRs comprises the second largest …

G protein coupled receptor 55 (GPR55) is expressed throughout the body, and although its
exact physiological function is unknown, studies have suggested a role in the cardiovascular …

Mechanotransduction plays a crucial role in vascular biology. One example of this is the
local regulation of vascular resistance via flow-mediated dilation (FMD). Impairment of this …