Lymphoid chemokines in the diagnosis, monitoring and treatment of inflammatory disease

BM Segal, L Bagaeva - US Patent 7,390,884, 2008 - Google Patents
Experimental autoimmune encephalomyelitis (EAE) is a Th1-mediated autoimmune disease
of the central nervous system that is widely used as an animal model of multiple sclerosis …

Lymphoid chemokines in the diagnosis, monitoring and treatment of inflammatory disease

BM Segal, L Bagaeva - US Patent 8,546,538, 2013 - Google Patents
Experimental autoimmune encephalomyelitis (EAE) is a Th1-mediated autoimmune disease
of the central nervous system that is widely used as an animal model of multiple sclerosis …

CXC chemokine ligand 13 plays a role in experimental autoimmune encephalomyelitis

LV Bagaeva, P Rao, JM Powers… - The Journal of …, 2006 - journals.aai.org
Experimental autoimmune encephalomyelitis (EAE) is a Tcell-mediated autoimmune
disease of the CNS that is widely used as an animal model of multiple sclerosis. In this …

Neutralization of the chemokine CXCL10 reduces inflammatory cell invasion and demyelination and improves neurological function in a viral model of multiple …

MT Liu, HS Keirstead, TE Lane - The Journal of Immunology, 2001 - journals.aai.org
Intracerebral infection of mice with mouse hepatitis virus (MHV) results in an acute
encephalomyelitis followed by a chronic demyelinating disease with clinical and histological …

Regulation of neuroinflammation: the role of CXCL10 in lymphocyte infiltration during autoimmune encephalomyelitis

RS Klein - Journal of cellular biochemistry, 2004 - Wiley Online Library
The movement of lymphocytes from the microvasculature into the central nervous system
(CNS) parenchyma is an essential step in the pathogenesis of a variety of infectious and …

Antagonism of the chemokine receptors CXCR3 and CXCR4 reduces the pathology of experimental autoimmune encephalomyelitis

RE Kohler, I Comerford, S Townley… - Brain …, 2008 - Wiley Online Library
Chemokines regulate lymphocyte trafficking under physiologic and pathologic conditions. In
this study, we have investigated the role of CXCR3 and CXCR4 in the activation of T …

CXCR3 signaling reduces the severity of experimental autoimmune encephalomyelitis by controlling the parenchymal distribution of effector and regulatory T cells in …

M Müller, SL Carter, MJ Hofer, P Manders… - The Journal of …, 2007 - journals.aai.org
The chemokine receptor CXCR3 promotes the trafficking of activated T and NK cells in
response to three ligands, CXCL9, CXCL10, and CXCL11. Although these chemokines are …

CXCL12 in control of neuroinflammation

M Momcilović, M Mostarica-Stojković, D Miljković - Immunologic research, 2012 - Springer
Inflammation within the central nervous system (CNS) is strictly controlled and if possible
prevented. Such a tight control is necessary due to high sensitivity of nervous tissue to …

Nitric oxide inhibits CXCL12 expression in neuroinflammation

F Petković, J Blaževski, M Momčilović… - Immunology and cell …, 2013 - Wiley Online Library
Chemokine CXCL12 (C‐X‐C motif chemokine ligand 12) restricts immune cell invasion of
the central nervous system (CNS) and limits neuroinflammation in experimental autoimmune …

CXCL10 (IFN-γ-inducible protein-10) control of encephalitogenic CD4+ T cell accumulation in the central nervous system during experimental autoimmune …

BT Fife, KJ Kennedy, MC Paniagua… - The Journal of …, 2001 - journals.aai.org
Experimental autoimmune encephalomyelitis (EAE) is a CD4+ Th1-mediated demyelinating
disease of the CNS that serves as a model for multiple sclerosis. A critical event in the …