Activation of the cyclic AMP (cAMP) signaling pathway leads to the suppression of
inflammation in the airways and relaxation of airway smooth muscle. Intracellular cAMP …

Despite extensive effort, only a few chronic obstructive pulmonary disease (COPD)-
associated genes have been suggested, indicating that there must be additional risk …

Chronic obstructive pulmonary disease (COPD) is characterized by airflow obstruction due
to chronic bronchitis, emphysema, and/or disease of small airways. It has been reported that …

Short-acting b2-adrenergic receptor agonists are commonly used bronchodilators for
symptom relief in asthmatics. The aim of this study was to test whether genetic variants in …

In inflammatory cells, the low Km cyclic adenosine monophosphate (cAMP)-specific
phosphodiesterase (PDE) 4 subtype is predominant in terms of expression and function …

The expression profile of a panel of 15 cAMP phosphodiesterase isoforms was determined
for inflammatory cell types of relevance to chronic obstructive pulmonary disease (COPD). In …

Background Genetic factors are believed to play a role in the individual susceptibility to
chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism (SNP) of …

To assess the role that polymorphisms of cytokine genes play in genetic predisposition to
chronic obstructive pulmonary disease (COPD), the allele and genotype distributions of …

Background Aspirin-exacerbated respiratory disease (AERD) is an endotype of severe and
eosinophilic adult asthma characterized by chronic rhinosinusitis with nasal polyps and …

Chronic obstructive pulmonary disease (COPD) is a multifactorial disorder characterized by
irreversible airflow obstruction due to chronic inflammation. Hence, the gene encoding the …