In this study, the correlation between the single nucleotide polymorphisms (SNPs) at
rs2910829 and rs918592 in the phosphodiesterase 4D (PDE4D) gene and cerebral …

Endothelin-1 (ET-1) has been implicated in the pathogenesis of Chronic Obstructive
Pulmonary Disease (COPD) for establishing an inflammatory loop in the respiratory mucosa …

IL-13 is strongly implicated in the development of asthma and chronic obstructive
polymonary disease (COPD). We previously identified an IL-13 promoter polymorphism …

Chronic obstructive pulmonary disease (COPD) is a complex disease, and its pathogenesis
is influenced by genetic factors. This study aimed to evaluate the role of IL5RA genetic …

BACKGROUND: Susceptibility to Chronic Obstructive Pulmonary Disease (COPD) has a
genetic component. We undertook a study to determine if a genetic variant of the gene …

Introduction Chronic obstructive pulmonary disease (COPD) is a lung disease closely
related to exposure to exogenous substances. CYP2B6 can activate many exogenous …

Background It is known that the contribution of risk alleles to chronic obstructive pulmonary
disease (COPD) may vary between populations. Further, previous studies involving various …

Background and objective: Cathepsin S is involved in the pathogenesis of COPD in murine
models overexpressing interferon (IFN)‐γ and IL‐13. It is widely accepted that genetic …

Inhibitors of phosphodiesterase-4 (PDE4) are efficacious for allergic asthma in animal
models and have shown some efficacy in human asthma. Regulation of PDE4 in allergy and …

Chronic inflammation and remodelling of the small airways are features related to chronic
obstructive pulmonary disease (COPD). In the current study, we aimed to explore the …