A molecular clock regulates angiopoietin-like protein 2 expression
T Kadomatsu, S Uragami, M Akashi, Y Tsuchiya… - PLoS …, 2013 - journals.plos.org
Various physiological and behavioral processes exhibit circadian rhythmicity. These rhythms
are usually maintained by negative feedback loops of core clock genes, namely, CLOCK …
are usually maintained by negative feedback loops of core clock genes, namely, CLOCK …
Insulin-like growth factor-1 acts as a zeitgeber on hypothalamic circadian clock gene expression via glycogen synthase kinase-3β signaling
A Breit, L Miek, J Schredelseker, M Geibel… - Journal of Biological …, 2018 - ASBMB
Brain and muscle ARNT-like protein-1 (BMAL-1) is an important component of the cellular
circadian clock. Proteins such as epidermal (EGF) or nerve growth factor (NGF) affect the …
circadian clock. Proteins such as epidermal (EGF) or nerve growth factor (NGF) affect the …
Circadian clock disruption attenuated growth hormone (GH)-mediated signalling
X Lyu, G Wang, Z Pi, L Wu - General and Comparative Endocrinology, 2021 - Elsevier
The circadian molecular clock is an internal time-keeping system, which regulates various
physiological processes through the generation of approximately 24-hour circadian rhythms …
physiological processes through the generation of approximately 24-hour circadian rhythms …
TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1
It has been reported that metabolites regulate circadian rhythms through direct effects on
clock genes. A metabolic network involving PER3 raises the possibility that some metabolic …
clock genes. A metabolic network involving PER3 raises the possibility that some metabolic …
The circadian protein BMAL1 supports endothelial cell cycle during angiogenesis
M Astone, RE Oberkersch, G Tosi… - Cardiovascular …, 2023 - academic.oup.com
Aims The circadian clock is an internal biological timer that co-ordinates physiology and
gene expression with the 24-h solar day. Circadian clock perturbations have been …
gene expression with the 24-h solar day. Circadian clock perturbations have been …
Chronic circadian shift leads to adipose tissue inflammation and fibrosis
The circadian clock exerts temporal coordination of metabolic pathways. Clock disruption is
intimately linked with the development of obesity and insulin resistance, and our previous …
intimately linked with the development of obesity and insulin resistance, and our previous …
[HTML][HTML] “Time” for obesity-related cancer: The role of the circadian rhythm in cancer pathogenesis and treatment
The circadian rhythm is regulated by an intrinsic time-tracking system, composed both of a
central and a peripheral clock, which influences the cycles of activities and sleep of an …
central and a peripheral clock, which influences the cycles of activities and sleep of an …
Exploring the role of circadian clock gene and association with cancer pathophysiology
M Keshvari, M Nejadtaghi… - Chronobiology …, 2020 - Taylor & Francis
Most of the processes that occur in the mind and body follow natural rhythms. Those with a
cycle length of about one day are called circadian rhythms. These rhythms are driven by a …
cycle length of about one day are called circadian rhythms. These rhythms are driven by a …
Chronobiology in mammalian health
Z Liu, G Chu - Molecular biology reports, 2013 - Springer
Circadian rhythms are daily cycles of physiology and behavior that are driven by an
endogenous oscillator with a period of approximately one day. In mammals, the …
endogenous oscillator with a period of approximately one day. In mammals, the …
Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation
S Shimba, T Ogawa, S Hitosugi, Y Ichihashi… - PloS one, 2011 - journals.plos.org
A link between circadian rhythm and metabolism has long been discussed. Circadian
rhythm is controlled by positive and negative transcriptional and translational feedback …
rhythm is controlled by positive and negative transcriptional and translational feedback …