Nitric oxide, bicarbonate, natriuretic peptides (ANP, BNP and CNP), guanylins, uroguanylins
and guanylyl cyclase activating proteins (GCAPs) activate a family of enzymes variously …

Guanylyl cyclases (GCs) are enzymes that convert guanosine-5′-triphosphate (GTP) to
cyclic guanosine-3′, 5′-monophosphate (cGMP). The second messenger cGMP …

Guanylyl cyclases, which catalyze the formation of the intracellular signal molecule cyclic
GMP from GTP, display structural features similar to other signal‐transducing enzymes such …

Soluble guanylyl cyclase is a heterodimer consisting of an α and β subunit and stimulation
occurs upon binding of NO to a prosthetic group. Little is known about the localization of …

This brief review focuses on guanylyl cyclase, an enzyme whose activity is known to be
associated with both soluble and particulate fractions of cell homogenates. The number of …

▪ Abstract During the 1980s the purification, cloning, and expression of various forms of
guanylyl cyclase (GC) revealed that they served as receptors for extracellular signals. Seven …

After its discovery in 1963 (1), scientists were challenged to define the cellular function of
guanosine 3', 5'-monophosphate (cGMP). The gauntlet was taken up by many, but despite …

Revised Manuscript Received January 10, 1995® abstract: Deletion mutagenesis was used
to identify sequences required for dimerization and enzymatic activity of the intracellular …

Guanylyl cyclases are a family of enzymes that catalyze the conversion of GTP to cGMP. The
family comprises both membrane-bound and soluble isoforms that are expressed in nearly …

The α1-and β1-subunits of human soluble guanylate cyclase (sGC) were coexpressed in the
Sf9 cells/baculovirus system. In addition to the native enzyme, constructs with hexahistidine …