The discovery of opiate receptors and endogenous opioid peptides within the central
nervous system has resulted in a number of speculations concerning the physiological …

Endogenous opioid signaling contributes to the neural control of food intake. Opioid
signaling is thought to regulate palatability, the reward value of a food item as determined by …

Numerous reports have described opioids as peptides involved in the regulation of food
intake. The role of these endogenous substances appears to be linked with reward …

Food reward can be driven by separable mechanisms of hedonic impact (food 'liking') and
incentive motivation (food 'wanting'). Brain mu-opioid systems contribute crucially to both …

There is substantial evidence for the role of endogenous opioid peptides in the regulation of
appetite. This communication examines the possible opioid peptide mechanism (s) which …

The present studies tested the effect of acute and chronic administration of naloxone on food
intake of lean and genetically obese (ob/ob) mice. Acute administration of naloxone, a drug …

Opioid signaling in the nucleus accumbens (NAcc) regulates feeding behavior, having
particularly strong effects on consumption of highly palatable foods. Since macronutrient …

Previous work from our laboratory indicates that when rats are given a choice between a
high-fat and a high-sucrose diet, opioid blockade with naltrexone (NTX) in a reward-related …

This paper and the following four papers summarize a symposium on the role of opioids in
regulation of feeding, body weight, and energy expenditure. The central sites of opioid …

Functional elucidation of the endogenous opioid system temporally paralleled the creation
and growth of the journal, Peptides, under the leadership of its founding editor, Dr. Abba …