Background Oxygen (O2) homeostasis is central to myocardial tissue functioning, and
increased O2 demand is thought to be satisfied by a vasodilatory mechanism that results in …

Background The relationship between mean arterial pressure (MAP) and coronary blood
flow is well described. There is autoregulation within a MAP range of 60 to 140 mmHg …

Background Myocardial oxygenation imaging could help determine the presence of
microvascular dysfunction associated with increased cardiovascular risk. However, it is …

Background As myocardial oxygenation may serve as a marker for ischemia and
microvascular dysfunction, it could be clinically useful to have a non-invasive measure of …

Background: The pathophysiology of heart failure with preserved ejection fraction is not well
understood, but evidence strongly suggests involvement of microvascular dysfunction. We …

Background Coronary artery disease and left ventricular hypertrophy are prevalent in the
chronic kidney disease (CKD) and renal transplant (RT) population. Advances in …

Oxygenation-sensitive cardiac magnetic resonance imaging (OS-CMR) is a diagnostic
technique that uses the inherent paramagnetic properties of deoxyhemoglobin as an …

Aims To explore the impact of the functional severity of coronary artery stenosis on changes
in myocardial oxygenation during pharmacological vasodilation, using oxygenation …

Background Myocardial fibrosis is observed in multiple cardiac conditions including
hypertension and aortic stenosis. Excessive fibrosis is associated with adverse clinical …

Purpose Quantification of myocardial oxygenation (MO) in heart failure (HF) has been less
than satisfactory. This has necessitated the use of invasive techniques to measure MO …